Antimicrobial peptides from fish: beyond the fight against pathogens

Fish antimicrobial peptides (AMPs) are small peptides whose actions have great implications in the innate immune response of teleost fish, being considered critical as the first line of defence against a wide spectrum of pathogens. Antibiotics have been widely used in aquaculture, resulting in bacte...

Full description

Saved in:
Bibliographic Details
Published in:Reviews in aquaculture 2020-02, Vol.12 (1), p.224-253
Main Authors: Valero, Yulema, Saraiva‐Fraga, Miguel, Costas, Benjamín, Guardiola, Francisco A.
Format: Article
Language:English
Subjects:
Adjuvants
Antibiotics
Anticancer properties
Antiinfectives and antibacterials
Antimicrobial peptides
antioxidant
Antioxidants
antitumour
Aquaculture
CRISPR
CRISPR‐Cas
Defence mechanisms
Drugs
Fish
fish antimicrobial peptides
Gene editing
host‐defence
Immune response
Immune system
Immunity
Immunogenicity
Immunosuppressive agents
Instruments
Methods
Pathogens
Peptides
Properties
vaccines
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fish antimicrobial peptides (AMPs) are small peptides whose actions have great implications in the innate immune response of teleost fish, being considered critical as the first line of defence against a wide spectrum of pathogens. Antibiotics have been widely used in aquaculture, resulting in bacterial resistance. The potential of AMPs as alternative to antibiotics makes them a very interesting tool as they represent lower‐risk peptides to develop resistances, or even in the fight against other pathogens such as viruses. Beyond their antimicrobial function, fish AMPs possess several relevant but little‐known characteristics and capabilities such as host‐defence peptides, antioxidants, active compounds of immunogenic drugs and as adjuvants. Moreover, their antitumour properties make them potential drugs to be used in oncological treatments in human subjects. Novel methodologies as clustered regularly interspaced short palindromic repeats associated proteins system (CRISPR‐Cas), or even their use as nutraceutics, seem to be promising instruments to enlarge the functions of fish AMPs. This review discusses these new methodologies, as well as the latest research on fish AMP functions, newly discovered properties of AMPs and their future applications in both the aquaculture industry and human health care.
ISSN:1753-5123
1753-5131
DOI:10.1111/raq.12314