253 Ovarian Sertoli-Leydig Cell Tumor Presenting With Nonspecific Symptoms, in an Elderly Patient With Family History of Gastrointestinal Stromal Tumor

Abstract Objectives Sertoli-Leydig cell tumors (SLCTs) of the ovary are rare sex cord stromal tumors, accounting for less than 0.1% of ovarian tumors. SLCTs typically occur in young women and usually manifest with symptoms related to androgen excess. We present the case of a 75-year-old female patie...

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Bibliographic Details
Published in:American journal of clinical pathology 2018-01, Vol.149 (suppl_1), p.S107-S108
Main Authors: Haque, Monira, Hameed, Nadia, Mneimneh, Wadad
Format: Article
Language:English
Subjects:
Abdomen
Calretinin
CD34 antigen
Colon
Computed tomography
Desmin
Differential diagnosis
Gastrointestinal cancer
Geriatrics
Growth patterns
Hemorrhage
Ileum
Inhibin
Leukocytes (eosinophilic)
Leydig cells
MART-1 antigen
Mitosis
Necrosis
Ovarian cancer
Pelvis
Tumors
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Summary:Abstract Objectives Sertoli-Leydig cell tumors (SLCTs) of the ovary are rare sex cord stromal tumors, accounting for less than 0.1% of ovarian tumors. SLCTs typically occur in young women and usually manifest with symptoms related to androgen excess. We present the case of a 75-year-old female patient with a family history of gastrointestinal stromal tumor (GIST) in the brother. Methods Clinically, she presented with abdominal swelling, weight loss and severe heartburn. Computed tomography revealed a heterogeneously hypoechoic, solid and cystic mass extending from the pelvis to upper abdomen, with a differential diagnosis including, mainly, an ovarian primary and GIST. The patient’s serum CA-125 was found to be 342 U/mL (reference range
ISSN:0002-9173
1943-7722
DOI:10.1093/ajcp/aqx123.252