Assessment of Programmed Death–Ligand 1 (PD-L1) Immunohistochemical Expression on Cytology Specimens in Non–Small Cell Lung Carcinoma: A Comparative Study With Paired Surgical Specimens

Objectives To evaluate whether non-small cell lung carcinoma (NSCLC) cytology specimens are reliable for programmed death–ligand 1 (PD-L1) immunohistochemical (IHC) testing. Methods Fifty-two cell blocks (CBs) with corresponding surgical pathology PD-L1 IHC testing were stained with a Dako PD-L1 pha...

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Bibliographic Details
Published in:American journal of clinical pathology 2019-04, Vol.151 (4), p.403-415
Main Authors: Hernandez, Andrea, Brandler, Tamar C, Zhou, Fang, Moreira, Andre L, Schatz-Siemers, Nina, Simsir, Aylin
Format: Article
Language:English
Subjects:
Agreements
Apoptosis
Cellular biology
Cytology
Immunotherapy
Ligands
Lung cancer
Lung carcinoma
Non-small cell lung carcinoma
PD-L1 protein
Small cell lung carcinoma
Tumor cells
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Summary:Objectives To evaluate whether non-small cell lung carcinoma (NSCLC) cytology specimens are reliable for programmed death–ligand 1 (PD-L1) immunohistochemical (IHC) testing. Methods Fifty-two cell blocks (CBs) with corresponding surgical pathology PD-L1 IHC testing were stained with a Dako PD-L1 pharmDX antibody (clone-22C3). Tumor cellularity was recorded as
ISSN:0002-9173
1943-7722
DOI:10.1093/ajcp/aqy164