0537 Positive Effects of Long Term Continuous Positive Airway Pressure (CPAP) Therapy on Blood Pressure in Obstructive Sleep Apnea Patients

• Published in: Sleep (New York, N.Y.) N.Y.), 2019-04, Vol.42 (Supplement_1), p.A215-A215
• Main Authors: Shirahama, Ryutaro, Tomooka, Kiyohide, Yun, Lan Fan, Ikeda, Ai, Endo, Tomoki, Wada, Hiroo, Kales, Stefanos N, Tanigawa, Takeshi
• Format: Article
• Language: English
• Subjects: Blood pressure; Continuous positive airway pressure; Hypertension; Regression analysis; Sleep apnea
• ISSN: 0161-8105; 1550-9109
• DOI: 10.1093/sleep/zsz067.535

Introduction OSA is one of the common causes of secondary hypertension. It leads to nocturnal and early morning hypertension and increased blood pressure fluctuation; these are the risks for cerebrovascular events. To investigate longitudinal effect of continuous positive airway pressure (CPAP) therapy and its adherence on blood pressure reduction in obstructive sleep apnea (OSA) and the relation between CPAP therapy and body weight change. Methods One thousand two hundred ninety-three (male 1,130, female 163) patients, who were diagnosed with OSA and underwent CPAP therapy, were investigated for longitudinal changes in blood pressure and body weight. Analysis of covariance was applied for comparison of mean values. Multiple linear regression analysis was performed to assess linear relations between continuous dependent variables. Logistic regression analysis was performed to assess binary dependent variables. MICE (Multiple Imputation with Chained Equations) was used to impute missing data. Results The patient group with good CPAP adherence (usage rate of CPAP ≧70% over 4 hours) showed significant blood pressure reduction compared to the poor CPAP adherence group (usage rate of CPAP < 70% over 4 hours) at 24 months observation period (p