Synthesis and Antitumor Activity of 3-Amino-3,4-Seco-Lupa-4(23),20(29)-Diene Derivatives

3-Amino-3,4-seco-lupa-4(23),20(29)-diene and its 3,28-bis (cyanoethyl) and 3-aminopropyl derivatives caused growth inhibition or death of nine human cancer cell lines. Leukemia, melanoma, and non-small-cell lung, colon, CNS, and kidney cancer cell lines were most sensitive to these compounds. Antitu...

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Bibliographic Details
Published in:Chemistry of natural compounds 2020, Vol.56 (1), p.92-97
Main Authors: Giniyatullina, G. V., Mustafin, A. G., Kazakova, O. B.
Format: Article
Language:English
Subjects:
Acetates
Anticancer properties
Biotechnology
Cancer
Colon
Derivatives
Leukemia
Medicine
Organic Chemistry
Pharmacy
Plant Sciences
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Summary:3-Amino-3,4-seco-lupa-4(23),20(29)-diene and its 3,28-bis (cyanoethyl) and 3-aminopropyl derivatives caused growth inhibition or death of nine human cancer cell lines. Leukemia, melanoma, and non-small-cell lung, colon, CNS, and kidney cancer cell lines were most sensitive to these compounds. Antitumor activity decreased with a tosyl group in the C-28 position or acetates on C-3 and C28.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-020-02951-1