Two Neoflavones from Aconitum Austroyunnanense and their Therapeutic Activity Against Osteoarthritis of the Knee

In this study, we isolated two new neoflavones from Aconitum austroyunnanense and examined their therapeutic activity against osteoarthritis of the knee. All the tested compounds displayed good anti-inflammatory activity and significantly therapeutic activity against osteoarthritis of rats using sur...

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Bibliographic Details
Published in:Chemistry of natural compounds 2020, Vol.56 (1), p.62-66
Main Authors: Xu, Ziqing, Wu, Shicheng, Huang, Guicheng, Ding, Hongwei, Zhu, Baohua, Guo, Yang
Format: Article
Language:English
Subjects:
Arthritis
Biomedical materials
Knee
Medicine
Organic Chemistry
Osteoarthritis
Pharmacy
Plant Sciences
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Summary:In this study, we isolated two new neoflavones from Aconitum austroyunnanense and examined their therapeutic activity against osteoarthritis of the knee. All the tested compounds displayed good anti-inflammatory activity and significantly therapeutic activity against osteoarthritis of rats using surgically induced rat OA models. Compound 1 has the best therapeutic activity and appears to be a promising candidate for further development.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-020-02944-0