A New Antibacterial Chlorinated Amino Acid Derivative from the Sponge-Derived Fungus Aspergillus sp. LS53

A new chlorinated amino acid derivative with a rare 3-chloro-4-hydroxyphenyl unit named aspergamide A ( 1 ), along with three known compounds, xylarinol A ( 2 ), nectriapyrone ( 3 ), and asperisocoumarin A ( 4 ), were isolated from the sponge-derived fungus Aspergillus sp. LS53. Their structures wer...

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Bibliographic Details
Published in:Chemistry of natural compounds 2020, Vol.56 (1), p.109-111
Main Authors: Zhang, Lu, Qiu, Panpan, Ding, Lijian, Li, Qiang, Song, Jingjing, Han, Zhiwen, He, Shan
Format: Article
Language:English
Subjects:
Amino acids
Antibacterial agents
Biological products
Fungi
Medicine
Organic Chemistry
Pharmacy
Plant Sciences
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Summary:A new chlorinated amino acid derivative with a rare 3-chloro-4-hydroxyphenyl unit named aspergamide A ( 1 ), along with three known compounds, xylarinol A ( 2 ), nectriapyrone ( 3 ), and asperisocoumarin A ( 4 ), were isolated from the sponge-derived fungus Aspergillus sp. LS53. Their structures were determined by combining detailed spectroscopic analysis and literature data. Compounds 1 , 3 , and 4 showed weak Vibrio harveyi inhibition with MIC values ranging from 16 to 64 μg/mL, whereas 2 was found to be inactive.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-020-02955-x