Versatile grafted microcrystalline cellulose with ionic liquid as new Losartan-controlled release material

[Display omitted] •Drug-delivery device based on a grafted cellulose with ionic liquid was obtained.•Grafted cellulose was used to adsorb/desorb Losartan as model pharmaceutical.•Grafted cellulose with ionic liquid generates a pH sensitive sorptive material.•Cationic cellulose was obtained with 76%...

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Bibliographic Details
Published in:European polymer journal 2020-02, Vol.124, p.109490, Article 109490
Main Authors: de Oliveira Santos, Stefânia Sales, Millán, Rubén Dário Sinisterra, Speziali, Marcelo Gomes
Format: Article
Language:English
Subjects:
Blood
Cellulose
Cellulose fibers
Chemical precipitation
Computer simulation
Controlled release
Crystalline cellulose
Desorption
Drug delivery systems
Electrolytes
Ionic liquids
Korsmeyer – Peppas kinetic model
Losartan
pH-dependent
Polymers
Reaction kinetics
Silanization
Stomach
Weibull kinetic model
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Summary:[Display omitted] •Drug-delivery device based on a grafted cellulose with ionic liquid was obtained.•Grafted cellulose was used to adsorb/desorb Losartan as model pharmaceutical.•Grafted cellulose with ionic liquid generates a pH sensitive sorptive material.•Cationic cellulose was obtained with 76% w/w of cellulose functionalization.•Ionic liquid was used as solvent and surface modifier. This paper describes the preparation and characterization of a versatile Losartan-controlled-release material based on a functionalized cellulosic matrix grafted with the ionic liquid, [(MeO)3Sipmim][Cl]: 1–(trimethoxysilylpropyl)–3–methylimidazolium Chloride. A silanized ionic liquid was used as a solvent and a surface modification agent at the same time, allowing higher anionic drug loading capacity. The anionic Losartan drug release kinetics were evaluated as a model. The Losartan release was made using two distinct media, one at pH 7.4 and the other at 3.0 to simulate blood and stomach pH, respectively. Higher Losartan release-rate 88% at blood pH after 1085 min in comparison with 84% at stomach pH, after 330 min was attained. The higher Losartan release profile in acid pH compared with neutral pH could be associated to the hydrolysis of Si-O bond from the ionic liquid, with the acidic medium acting as a catalyst. This cellulosic matrix modified with ionic liquid showed promising for applications over a wide range of pH-controlled-release systems.
ISSN:0014-3057
1873-1945
DOI:10.1016/j.eurpolymj.2020.109490