Versatile magnetic microdiscs for the radio enhancement and mechanical disruption of glioblastoma cancer cells

This study describes the use of highly versatile, lithographically defined magnetic microdiscs. Gold covered magnetic microdiscs are used in both radiosensitizing cancer cells, acting as intracellular emitters of secondary electrons during radiotherapy, and as well as inducing mechanical damage by e...

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Bibliographic Details
Published in:RSC advances 2020-02, Vol.1 (14), p.8161-8171
Main Authors: Leulmi Pichot, Selma, Bentouati, Sabrina, Ahmad, Saif S, Sotiropoulos, Marios, Jena, Raj, Cowburn, Russell
Format: Article
Language:English
Subjects:
Brain cancer
Cancer
Chemistry
Disruption
Emitters
Emitters (electron)
Radiation damage
Radiation therapy
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Summary:This study describes the use of highly versatile, lithographically defined magnetic microdiscs. Gold covered magnetic microdiscs are used in both radiosensitizing cancer cells, acting as intracellular emitters of secondary electrons during radiotherapy, and as well as inducing mechanical damage by exerting a mechanical torque when exposed to a rotating magnetic field. This study reveals that lithographically defined microdiscs with a uniform size of 2 microns in diameter highly increase the DNA damage and reduce the glioblastoma colony formation potential compared to conventional radiation therapy. Furthermore, the addition of mechanical disruption mediated by the magnetic component of the discs increased the efficiency of brain cancer cell killing. First study demonstrating the use of physically engineered magnetic particles that display two functionalities for cancer treatment.
ISSN:2046-2069
2046-2069
DOI:10.1039/d0ra00164c