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MicroRNAs in breast cancer: Roles, functions, and mechanism of actions
Breast cancer is one of the most lethal malignancies in women in the world. Various factors are involved in the development and promotion of the malignancy; most of them involve changes in the expression of certain genes, such as microRNAs (miRNAs). MiRNAs can regulate signaling pathways negatively...
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| Published in: | Journal of cellular physiology 2020-06, Vol.235 (6), p.5008-5029 |
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| creator | Abolghasemi, Maryam Tehrani, Sadra Samavarchi Yousefi, Tooba Karimian, Ansar Mahmoodpoor, Ata Ghamari, Aliakbar Jadidi‐Niaragh, Farhad Yousefi, Mehdi Kafil, Hossein Samadi Bastami, Milad Edalati, Mahdi Eyvazi, Shirin Naghizadeh, Mohsen Targhazeh, Niloufar Yousefi, Bahman Safa, Amin Majidinia, Maryam Rameshknia, Vahid |
| description | Breast cancer is one of the most lethal malignancies in women in the world. Various factors are involved in the development and promotion of the malignancy; most of them involve changes in the expression of certain genes, such as microRNAs (miRNAs). MiRNAs can regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of cancer progression, particularly breast cancer. Besides, accumulating data demonstrated that miRNAs are a novel tool for prognosis and diagnosis of breast cancer patients. Herein, we will review the roles of these RNA molecules in several important signaling pathways, such as transforming growth factor, Wnt, Notch, nuclear factor‐κ B, phosphoinositide‐3‐kinase/Akt, and extracellular‐signal‐regulated kinase/mitogen activated protein kinase signaling pathways in breast cancer.
Various factors are involved in the development and promotion of breast cancer. MicroRNAs (miRNAs) regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of breast cancer progression. We review the roles of miRNAs in signaling pathways in breast cancer. |
| doi_str_mv | 10.1002/jcp.29396 |
| format | article |
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Various factors are involved in the development and promotion of breast cancer. MicroRNAs (miRNAs) regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of breast cancer progression. We review the roles of miRNAs in signaling pathways in breast cancer.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.29396</identifier><identifier>PMID: 31724738</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>AKT protein ; biomarker ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; cancer ; Carcinogenesis - genetics ; diagnosis ; Female ; Gene expression ; Growth factors ; Humans ; Kinases ; Malignancy ; MAP Kinase Signaling System - genetics ; MicroRNAs ; MicroRNAs - genetics ; miRNA ; NF-kappa B - genetics ; Phosphatidylinositol 3-Kinase - genetics ; prognosis ; Protein kinase ; Receptors, Notch - genetics ; signal pathway ; Signal transduction ; Signal Transduction - genetics ; Signaling ; Tumorigenesis ; Wnt protein ; Wnt Proteins - genetics</subject><ispartof>Journal of cellular physiology, 2020-06, Vol.235 (6), p.5008-5029</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-e1292cac73a204ae2ec49f1c209d5cea233a89d9400231f00586838d8d1e39a63</citedby><cites>FETCH-LOGICAL-c3536-e1292cac73a204ae2ec49f1c209d5cea233a89d9400231f00586838d8d1e39a63</cites><orcidid>0000-0002-4220-1527 ; 0000-0002-4641-882X ; 0000-0002-9216-6512 ; 0000-0002-7686-4505 ; 0000-0001-9776-5816 ; 0000-0001-9823-5454</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31724738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abolghasemi, Maryam</creatorcontrib><creatorcontrib>Tehrani, Sadra Samavarchi</creatorcontrib><creatorcontrib>Yousefi, Tooba</creatorcontrib><creatorcontrib>Karimian, Ansar</creatorcontrib><creatorcontrib>Mahmoodpoor, Ata</creatorcontrib><creatorcontrib>Ghamari, Aliakbar</creatorcontrib><creatorcontrib>Jadidi‐Niaragh, Farhad</creatorcontrib><creatorcontrib>Yousefi, Mehdi</creatorcontrib><creatorcontrib>Kafil, Hossein Samadi</creatorcontrib><creatorcontrib>Bastami, Milad</creatorcontrib><creatorcontrib>Edalati, Mahdi</creatorcontrib><creatorcontrib>Eyvazi, Shirin</creatorcontrib><creatorcontrib>Naghizadeh, Mohsen</creatorcontrib><creatorcontrib>Targhazeh, Niloufar</creatorcontrib><creatorcontrib>Yousefi, Bahman</creatorcontrib><creatorcontrib>Safa, Amin</creatorcontrib><creatorcontrib>Majidinia, Maryam</creatorcontrib><creatorcontrib>Rameshknia, Vahid</creatorcontrib><title>MicroRNAs in breast cancer: Roles, functions, and mechanism of actions</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Breast cancer is one of the most lethal malignancies in women in the world. Various factors are involved in the development and promotion of the malignancy; most of them involve changes in the expression of certain genes, such as microRNAs (miRNAs). MiRNAs can regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of cancer progression, particularly breast cancer. Besides, accumulating data demonstrated that miRNAs are a novel tool for prognosis and diagnosis of breast cancer patients. Herein, we will review the roles of these RNA molecules in several important signaling pathways, such as transforming growth factor, Wnt, Notch, nuclear factor‐κ B, phosphoinositide‐3‐kinase/Akt, and extracellular‐signal‐regulated kinase/mitogen activated protein kinase signaling pathways in breast cancer.
Various factors are involved in the development and promotion of breast cancer. MicroRNAs (miRNAs) regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of breast cancer progression. We review the roles of miRNAs in signaling pathways in breast cancer.</description><subject>AKT protein</subject><subject>biomarker</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>cancer</subject><subject>Carcinogenesis - genetics</subject><subject>diagnosis</subject><subject>Female</subject><subject>Gene expression</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Kinases</subject><subject>Malignancy</subject><subject>MAP Kinase Signaling System - genetics</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>NF-kappa B - genetics</subject><subject>Phosphatidylinositol 3-Kinase - genetics</subject><subject>prognosis</subject><subject>Protein kinase</subject><subject>Receptors, Notch - genetics</subject><subject>signal pathway</subject><subject>Signal transduction</subject><subject>Signal Transduction - genetics</subject><subject>Signaling</subject><subject>Tumorigenesis</subject><subject>Wnt protein</subject><subject>Wnt Proteins - genetics</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LAzEQhoMotlYP_gEJeCq4bZLJfoy3Uqwf1A-KnkOazeKW7m5Nukj_vdGt3jzNwDy8M_MQcs7ZiDMmxiuzGQkETA5InzNMI5nE4pD0w4xHGEveIyferxhjiADHpAc8FTKFrE9mj6VxzeJp4mlZ06Wz2m-p0bWx7poumrX1V7Roa7Mtmzq0us5pZc27rktf0aagupuckqNCr70929cBeZvdvE7vovnz7f10Mo8MxJBElgsURpsUtGBSW2GNxIIbwTCPjdUCQGeYowyXAy8Yi7MkgyzPcm4BdQIDctnlblzz0Vq_VaumdXVYqQQkmMoYEwzUsKPCa947W6iNKyvtdooz9W1MBWPqx1hgL_aJ7bKy-R_5qygA4w74LNd293-Sepi-dJFfxCFy3w</recordid><startdate>202006</startdate><enddate>202006</enddate><creator>Abolghasemi, Maryam</creator><creator>Tehrani, Sadra Samavarchi</creator><creator>Yousefi, Tooba</creator><creator>Karimian, Ansar</creator><creator>Mahmoodpoor, Ata</creator><creator>Ghamari, Aliakbar</creator><creator>Jadidi‐Niaragh, Farhad</creator><creator>Yousefi, Mehdi</creator><creator>Kafil, Hossein Samadi</creator><creator>Bastami, Milad</creator><creator>Edalati, Mahdi</creator><creator>Eyvazi, Shirin</creator><creator>Naghizadeh, Mohsen</creator><creator>Targhazeh, Niloufar</creator><creator>Yousefi, Bahman</creator><creator>Safa, Amin</creator><creator>Majidinia, Maryam</creator><creator>Rameshknia, Vahid</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-4220-1527</orcidid><orcidid>https://orcid.org/0000-0002-4641-882X</orcidid><orcidid>https://orcid.org/0000-0002-9216-6512</orcidid><orcidid>https://orcid.org/0000-0002-7686-4505</orcidid><orcidid>https://orcid.org/0000-0001-9776-5816</orcidid><orcidid>https://orcid.org/0000-0001-9823-5454</orcidid></search><sort><creationdate>202006</creationdate><title>MicroRNAs in breast cancer: Roles, functions, and mechanism of actions</title><author>Abolghasemi, Maryam ; 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Various factors are involved in the development and promotion of the malignancy; most of them involve changes in the expression of certain genes, such as microRNAs (miRNAs). MiRNAs can regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of cancer progression, particularly breast cancer. Besides, accumulating data demonstrated that miRNAs are a novel tool for prognosis and diagnosis of breast cancer patients. Herein, we will review the roles of these RNA molecules in several important signaling pathways, such as transforming growth factor, Wnt, Notch, nuclear factor‐κ B, phosphoinositide‐3‐kinase/Akt, and extracellular‐signal‐regulated kinase/mitogen activated protein kinase signaling pathways in breast cancer.
Various factors are involved in the development and promotion of breast cancer. MicroRNAs (miRNAs) regulate signaling pathways negatively or positively, thereby affecting tumorigenesis and various aspects of breast cancer progression. We review the roles of miRNAs in signaling pathways in breast cancer.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31724738</pmid><doi>10.1002/jcp.29396</doi><tpages>22</tpages><orcidid>https://orcid.org/0000-0002-4220-1527</orcidid><orcidid>https://orcid.org/0000-0002-4641-882X</orcidid><orcidid>https://orcid.org/0000-0002-9216-6512</orcidid><orcidid>https://orcid.org/0000-0002-7686-4505</orcidid><orcidid>https://orcid.org/0000-0001-9776-5816</orcidid><orcidid>https://orcid.org/0000-0001-9823-5454</orcidid></addata></record> |
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| subjects | AKT protein biomarker Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology cancer Carcinogenesis - genetics diagnosis Female Gene expression Growth factors Humans Kinases Malignancy MAP Kinase Signaling System - genetics MicroRNAs MicroRNAs - genetics miRNA NF-kappa B - genetics Phosphatidylinositol 3-Kinase - genetics prognosis Protein kinase Receptors, Notch - genetics signal pathway Signal transduction Signal Transduction - genetics Signaling Tumorigenesis Wnt protein Wnt Proteins - genetics |
| title | MicroRNAs in breast cancer: Roles, functions, and mechanism of actions |
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