Intra-uterine growth restriction induced by maternal low-protein diet causes long-term alterations of thymic structure and function in adult male rat offspring

Early malnutrition, the first environmental cause of intra-uterine growth restriction, impairs development of the thymus. Alterations of the thymic structure and function are reported at young ages in murine and ovine models. However, descriptions of thymic consequences of fetal malnutrition at adul...

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Bibliographic Details
Published in:British journal of nutrition 2020-04, Vol.123 (8), p.892-900
Main Authors: Armengaud, Jean-Baptiste, Dennebouy, Zelie, Labes, Danny, Fumey, Catherine, Wilson, Anne, Candotti, Fabio, Yzydorczyk, Catherine, Simeoni, Umberto
Format: Article
Language:English
Subjects:
Animal models
Animals
Antigens
Body Weight - drug effects
Bone marrow
CD3 antigen
CD4 antigen
CD8 antigen
Cloning
Diet
Diet, Protein-Restricted - adverse effects
Exposure
Female
Fetal Growth Retardation
Fetuses
Forkhead protein
Foxp3 protein
Gene expression
Gestation
Immunoglobulins
Low protein diet
Lymphocytes
Lymphotoxin
Male
Malnutrition
Nutrient deficiency
Nutrition research
Offspring
Pregnancy
Prenatal Exposure Delayed Effects
Prenatal Nutritional Physiological Phenomena
Protein structure
Proteins
Rats
Sex Factors
Structure-function relationships
Thymus
Thymus Gland - drug effects
Uterus
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Summary:Early malnutrition, the first environmental cause of intra-uterine growth restriction, impairs development of the thymus. Alterations of the thymic structure and function are reported at young ages in murine and ovine models. However, descriptions of thymic consequences of fetal malnutrition at adulthood are scarce. The present study investigates thymic structure, protein expression and cell selection process observed at postnatal day 180 (PND180) in male offspring of rats exposed to maternal low-protein diet (mLPD) compared with control diet during gestation. The thymic index was lower in adult offspring exposed to mLPD (P 
ISSN:0007-1145
1475-2662
DOI:10.1017/S000711452000015X