Exosomes Secretion and Autophagy in Long-Term Protection of Neurons from Excitotoxic Damage

— Exosome secretion has been demonstrated in the model of induced neuronal resistance to the toxic effect of glutamate (deprivation of trophic factors). Exosomes secretion occurring in the course of development of resistance during deprivation and at the first 24 h after preconditioning, as was show...

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Published in:Biochemistry (Moscow). Supplement. Series B, Biomedical chemistry Biomedical chemistry, 2020, Vol.14 (1), p.1-5
Main Authors: Yakovlev, A. A., Lyzhin, A. A., Aleksandrova, O. P., Khaspekov, L. G., Gulyaeva, N. V.
Format: Article
Language:English
Subjects:
Autophagy
Bioorganic Chemistry
CD63 antigen
Chemistry
Chemistry and Materials Science
Excitotoxicity
Exosomes
Long-term effects
Medicinal Chemistry
Phagocytosis
Secretion
Trophic factors
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Summary:— Exosome secretion has been demonstrated in the model of induced neuronal resistance to the toxic effect of glutamate (deprivation of trophic factors). Exosomes secretion occurring in the course of development of resistance during deprivation and at the first 24 h after preconditioning, as was shown by dot blot of extracellular fluid using anti-CD63 antibody. The autophagy inhibitor bafilomycin (0.01 µM) significantly reduced the quantity of the secreted exosomes at the stage of autophagy induction and during the first 24 h after induction. At the same time, inhibition of autophagy during trophic factor deprivation prevented the development of resistance, while inhibition of autophagy during the first 24 h after deprivation did not affect the development of resistance. We suggest that the long-term effects of preconditioning may be mediated by exosome secretion.
ISSN:1990-7508
1990-7516
DOI:10.1134/S1990750820010151