A novel amperometric hydrogen peroxide sensor based on gold nanoparticles supported on Fe3O4@polyethyleneimine

Herein, gold nanoparticles supported on polyethyleneimine functionalised magnetic nanoparticles (Fe 3 O 4 @PEI@Au NPs) were successfully synthesised and applied for non-enzymatic detection of hydrogen peroxide (H 2 O 2 ) in biological samples. The characterisation of Fe 3 O 4 @PEI@Au NPs was thoroug...

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Bibliographic Details
Published in:International journal of environmental analytical chemistry 2020-04, Vol.100 (5), p.591-601
Main Authors: Ghanei-Motlagh, Masoud, Hosseinifar, Abdurahman
Format: Article
Language:English
Subjects:
Amperometry
Analytical methods
Biological properties
Biological samples
Coated electrodes
Detection
Electrical measurement
Electron microscopy
Fourier transforms
Gold
Gold nanoparticles
human serum
Hydrogen peroxide
Infrared spectroscopy
Iron oxides
magnetic nanoparticles
Microscopy
Nanoparticles
Optimization
Polyethyleneimine
Scanning electron microscopy
Sensors
Serum
Spectrum analysis
Transmission electron microscopy
X rays
X-ray diffraction
X-ray spectroscopy
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Summary:Herein, gold nanoparticles supported on polyethyleneimine functionalised magnetic nanoparticles (Fe 3 O 4 @PEI@Au NPs) were successfully synthesised and applied for non-enzymatic detection of hydrogen peroxide (H 2 O 2 ) in biological samples. The characterisation of Fe 3 O 4 @PEI@Au NPs was thoroughly explored by transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and energy dispersive X-ray spectroscopy (EDX). Because of the large surface area of Au NPs, the prepared magnetic NPs were employed as an efficient electrocatalyst for reduction of H 2 O 2 . A graphite rod electrode (GRE) coated with Fe 3 O 4 @PEI@Au NPs was used for the amperometric determination of H 2 O 2 . After optimisation, the proposed sensor depicted a wide linear range from 0.2 to 500.0 μM with a low detection limit of 0.07 μM. In addition, the suggested method showed high sensitivity, good reproducibility and notable anti-interference property in the measuring of H 2 O 2 . The assay was credibly applied to determine H 2 O 2 concentration in human serum samples.
ISSN:0306-7319
1029-0397
DOI:10.1080/03067319.2019.1637859