Stable Polymer Nanoparticles with Exceptionally High Drug Loading by Sequential Nanoprecipitation

Poor solubility often leads to low drug efficacy. Encapsulation of water‐insoluble drugs in polymeric nanoparticles offers a solution. However, low drug loading remains a critical challenge. Now, a simple and robust sequential nanoprecipitation technology is used to produce stable drug‐core polymer‐...

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Bibliographic Details
Published in:Angewandte Chemie 2020-03, Vol.132 (12), p.4750-4758
Main Authors: Liu, Yun, Yang, Guangze, Baby, Thejus, Tengjisi, Chen, Dong, Weitz, David A., Zhao, Chun‐Xia
Format: Article
Language:English
Subjects:
Chemical precipitation
Chemistry
Drug delivery
Drug delivery systems
Hydrophobe Wirkstoffe
Nanofällung
Nanoparticles
Organic solvents
Polymernanopartikel
Polymers
Solvents
Technology
Wirkstoffbeladung
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Summary:Poor solubility often leads to low drug efficacy. Encapsulation of water‐insoluble drugs in polymeric nanoparticles offers a solution. However, low drug loading remains a critical challenge. Now, a simple and robust sequential nanoprecipitation technology is used to produce stable drug‐core polymer‐shell nanoparticles with high drug loading (up to 58.5 %) from a wide range of polymers and drugs. This technology is based on tuning the precipitation time of drugs and polymers using a solvent system comprising multiple organic solvents, which allows the formation of drug nanoparticles first followed by immediate precipitation of one or two polymers. This technology offers a new strategy to manufacture polymeric nanoparticles with high drug loading having good long‐term stability and programmed release and opens a unique opportunity for drug delivery applications. Ein einfacher Ansatz zur Nanofällung wird verwendet, um aus einer breiten Palette von Polymeren und Wirkstoffen Nanopartikel mit Medikamentenkern und Polymerhülle mit außergewöhnlich hoher Wirkstoffbeladung (bis zu 58.5 %) herzustellen. Diese Technik basiert auf der Abstimmung der Fällungszeit von Medikamenten und Polymeren mithilfe eines gemischten Lösungsmittelsystems.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201913539