Protein Microarray Analysis of Soluble Biomarkers in Fertile and Postmenopausal Women in Relation to Obesity, Bone Status and Blood Cell Populations

Abstract Objective: The purpose of the present study was to quantify serological biomarkers, namely adiponectin, leptin, E-selectin, ICAM-1 (intercelluar cell adhesion molecule-1), IGF-1 (insulin-like growth factor 1), MCSF (macrophage colony-stimulationg factor), IL-6, IL-10 and IL-17), in fertile...

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Bibliographic Details
Published in:Health science journal 2020-01, Vol.14 (1), p.1-11
Main Authors: Horvathova, Mira, Szabova, Michaela, Stefikova, Kornelia, Tulinska, Jana, Krivosikova, Zora, Spustova, Viera, Lískova, Aurelia, Gajdos, Martin
Format: Article
Language:English
Subjects:
Biomarkers
Body mass index
Hormone replacement therapy
Insulin-like growth factors
Liver cirrhosis
Obesity
Womens health
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Summary:Abstract Objective: The purpose of the present study was to quantify serological biomarkers, namely adiponectin, leptin, E-selectin, ICAM-1 (intercelluar cell adhesion molecule-1), IGF-1 (insulin-like growth factor 1), MCSF (macrophage colony-stimulationg factor), IL-6, IL-10 and IL-17), in fertile and postmenopausal women. Vascular Cell Adhesion Molecule Introduction Postmenopausal women are susceptible for environmental or genetic factors, and may experience a progression or initiation of diverse diseases such as obesity, osteoporosis and coronary heart disease, triggered by a systemic change in the balance of proinflammatory cytokine activity. [...]we evaluated the correlation between soluble biomarkers and cell populations, in fertile and postmenopausal women samples. Criteria for exclusion were acute physical illness or unstable physical condition, pregnancy, daily smoking for over a one year, nephropathy with glomerular filtration rate (GFR
ISSN:1791-809X
1791-809X
DOI:10.36648/1791-809X.14.1.691