A Multisensory Stripping Voltammetry Method for Analysis of the Generic Anti-Glaucoma Drug Betoptic

A new electrochemical method for multisensory stripping voltammetry has been used to determine whether it is appropriate for determination of generic forms of the drug Betoptic, that is, Xonef, Betoftan, and Betalink EU in tear fluid. Measurements were carried out on a planar three-electrode interdi...

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Bibliographic Details
Published in:Biophysics (Oxford) 2019-11, Vol.64 (6), p.885-889
Main Authors: Balashova, L. M., Kolesnichenko, I. I., Namiot, V. A., Doronin, A. N., Bakunina, N. A., Kuznetsova, Yu. D., Udaltsov, S. N.
Format: Article
Language:English
Subjects:
Biological and Medical Physics
Biophysics
Electrodes
Glaucoma
Molecular Biophysics
Physics
Physics and Astronomy
Voltammetry
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Summary:A new electrochemical method for multisensory stripping voltammetry has been used to determine whether it is appropriate for determination of generic forms of the drug Betoptic, that is, Xonef, Betoftan, and Betalink EU in tear fluid. Measurements were carried out on a planar three-electrode interdigitated electrode. It has been shown that this method is effective for determination of the generics. The dynamics of changes in their concentrations over time were examined. After instillation of the generics in glaucoma patients, their concentrations in the lacrimal fluid remained unchanged within 12 h. The list of organic substances that can be determined by the method of multisensory stripping voltammetry has been extended.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350919060046