Cancer stem cells as therapeutic targets of pancreatic cancer

The discovery of stem cells and their potential abilities in self‐renewal and differentiation has opened a new horizon in medicine. Scientists have found a small population of stem cells in some types of cancers with the same functions as normal stem cells. There are two models for tumor progression...

Full description

Saved in:
Bibliographic Details
Published in:Fundamental & clinical pharmacology 2020-04, Vol.34 (2), p.202-212
Main Authors: Razi, Ebrahim, Radak, Mehran, Mahjoubin-Tehran, Maryam, Talebi, Samaneh, Shafiee, Alimohammad, Hajighadimi, Sarah, Moradizarmehri, Sanaz, Sharifi, Hossein, Mousavi, Nousin, Sarvizadeh, Mostafa, Nejati, Majid, Taghizadeh, Mohsen, Ghasemi, Faezeh
Format: Article
Language:English
Subjects:
Cancer
cancer stem cell
Carcinogens
Cell culture
Cell self-renewal
Drug resistance
Metastases
Pancreatic cancer
Pharmacology
Stem cells
Therapeutic applications
therapeutic targets
Transformed cells
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The discovery of stem cells and their potential abilities in self‐renewal and differentiation has opened a new horizon in medicine. Scientists have found a small population of stem cells in some types of cancers with the same functions as normal stem cells. There are two models for tumor progression: clonal (stochastic) and cancer stem cell (CSCs) models. According to the first model, all transformed cells in the tumor have carcinogenic potential and are able to proliferate and produce the same cells. The latter model, which has received more attention recently, considers the role of CSCs in drug resistance and tumor metastasis. Following the model, researchers have found that targeting CSCs may be a promising way in cancer therapy. This review describes CSC characteristics in general, while also focusing on CSC properties in the context of pancreatic cancer.
ISSN:0767-3981
1472-8206
DOI:10.1111/fcp.12521