A sensitive “ON–OFF” fluorescent probe based on carbon dots for Fe2+ detection and cell imaging

Fe2+ is a trace metal ion required by the human body, and its abnormal metabolism can cause serious diseases. Herein, we report the development of a highly efficient “ON–OFF” fluorescent probe based on carbon dots (CDs), prepared by a simple one-step hydrothermal method. The CDs exhibited exceptiona...

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Bibliographic Details
Published in:Analyst (London) 2020-03, Vol.145 (6), p.2357-2366
Main Authors: Wei, Shanshan, Tan, Lihong, Yin, Xiangyu, Wang, Ruoming, Xueru Shan, Chen, Qian, Li, Tinghua, Zhang, Xinyu, Jiang, Chunzhu, Sun, Guoying
Format: Article
Language:English
Subjects:
Ascorbic acid
Carbon dots
Copper
Drinking water
Ferrous ions
Fluorescent indicators
Selectivity
Tartaric acid
Toxicity
Trace metals
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Summary:Fe2+ is a trace metal ion required by the human body, and its abnormal metabolism can cause serious diseases. Herein, we report the development of a highly efficient “ON–OFF” fluorescent probe based on carbon dots (CDs), prepared by a simple one-step hydrothermal method. The CDs exhibited exceptional water dispersibility and stability, superior luminescence performance and low cytotoxicity. The fluorescence could be efficiently quenched by Fe2+ through an electronic transfer process. And under the optimized experimental conditions, this probe shows excellent selectivity and high sensitivity towards Fe2+ with a detection limit of 51 nmol. More interestingly, this probe could realize the visual detection of Fe2+ when Fe3+ and Cu2+ ions were efficiently shielded by tartaric acid in the presence of ascorbic acid. Furthermore, the developed fluorescent probe has been successfully applied for the detection of Fe2+ in tap water and BSA solution as well as for the biosensing of Fe2+ in living cells.
ISSN:0003-2654
1364-5528
DOI:10.1039/c9an02309g