Synthesis, Characterization and Study of its In Vitro Biological Activity of the compound 4, 4’-Dimethoxy benzil and its Iron Oxide Nano Composite

[...]the development of new antibacterial agents that could overcome the resistance problem has become the subject of an ongoing research4-9. With this information we can find out new drugs and also make new synthetic compounds and lead molecules with different mechanism of actions and thereby diffe...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2019-11, Vol.12 (11), p.5524-5528
Main Authors: Nithya, G, Sudha, R
Format: Article
Language:English
Subjects:
Antimicrobial agents
Bacteria
Biological activity
Ethanol
Hydrocarbons
Pathogens
Pneumonia
Studies
Online Access:Get full text
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Summary:[...]the development of new antibacterial agents that could overcome the resistance problem has become the subject of an ongoing research4-9. With this information we can find out new drugs and also make new synthetic compounds and lead molecules with different mechanism of actions and thereby different target organisms especially against drug resistant bacteria and emerging microbes. The three Gram positive bacteria studied were Bacillus subtilis (ATCC 441), Staphylococcus aureus (ATCC 25923), Staphylococcus epidermidis (MTCC 3615) and the two Gram negative bacteria studied were E.coli (ATCC 25922), Klebsiella pneumoniae (ATCC15380). The pathogens Bacillus subtilis, Staphylococcus epidermidis and Klebsiella pneumoniae were found to exhibit similar anti bacterial activity for the compound 4,4'-dimethoxy benzil. [...]the activity of compounds against various pathogens is mainly in a dose dependent manner that is by increasing the dose from 25, 50 and 100 (pg) the activity also increases.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2019.00958.2