Formulation Development and Optimization of Tramadol Hydrochloride Fast Dissolving Tablets with Natural Superdisintegrant

• Published in: Research journal of pharmacy and technology 2019-11, Vol.12 (11), p.5389-5392
• Main Authors: Nagaraja, J., Rao, M. Prasada, Naik, M. Bhanu, Komali, D., Bai, N. Aswini, ranjani, G. Sri
• Format: Article
• Language: English
• Subjects: Drug dosages; Pain
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.5958/0974-360X.2019.00935.1

Extensive swelling, porosity and wicking action of the natural material in the fast dissolving tablet formulation were found to be contributing its superdisintegrant action as comparable to synthetic superdisintegrants shown in literature. The center for drug Evaluation and Research states an FDT to be: "A solid dosage form containing medicinal substances, which disintegrate rapidly, usually within a matter of seconds, when placed upon the tongue.1,2,3 Tramadol is a centrally acting synthetic analgesic, it is used in the treatment of moderate to severe pain. Tablets were dedusted using a soft muslin cloth and reweighed. ... d. Wetting time and Water absorption ratio: A piece of paper folded twice was kept in a petri dish (internal diameter 6cms) containing 6ml of purified water. The absorption spectra shown in Fig. 1 Standard Calibration curve of Tramadol HCl: Standard graph of Tramadol Hcl in pH 6.8 phosphate was plotted by taking concentration ranging from 2 to 20 pg/mL and a good correlation was obtained with R2 value of 0.999.