Combined effects of E. Jambolana and C. zeylanicum extract in insulin resistance associated Structural and Functional Hepatic changes in high Fructose-fed rats

[...]the combined effects of Jamun and cinnamon extracts exert antihyperglycemic, antitriglyceridemic, antioxidant, anti-inflammatory, and anti-steatosis properties in HFr fed rats. [...]it offers a promising value in the management of IR associated hepatic changes. Fructose intake stimulates de nov...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2019-12, Vol.12 (12), p.5765-5772
Main Authors: Bayya, M.H.R.K. Gupatha, Prasad, H.L Kishan, Adiga, M.N Sachidananda, Adiga, Usha Sachidanada
Format: Article
Language:English
Subjects:
Animals
Dehydrogenases
Diabetes
Diet
Homeostasis
Hyperglycemia
Insulin resistance
Liver
Liver cirrhosis
Metabolism
Obesity
Oxidative stress
Rodents
Seeds
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Summary:[...]the combined effects of Jamun and cinnamon extracts exert antihyperglycemic, antitriglyceridemic, antioxidant, anti-inflammatory, and anti-steatosis properties in HFr fed rats. [...]it offers a promising value in the management of IR associated hepatic changes. Fructose intake stimulates de novo lipogenesis which induces lipotoxicity at insulinsensitive tissues. [...]fat deposition diverts from adipose to hepatocytes may develop hepatic IR (central) accompanied by steatosis, a part of NAFLD. In NAFLD spectrum, which progress from steatosis, steatohepatitis, fibrosis, and cirrhosis could be mostly due to the involvement of IR, lipid peroxidation, and inflammation7. [...]the treatment of fatty liver in diabetes and obesity is with ursodiol, gemfibrozil, clofibrate, vitamin E, and insulin sensitizers are recommended, but still, complications exist. [...]the management of IR in the initial stages may halt the progression of hepatic steatosis that may be achieved with medicinal plants6,8.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2019.00998.3