Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells

One new indole alkaloid, reflexin A (1), and two known indoles, macusine B (2) and vinorine (3), were isolated from the bark of Rauvolfia reflexa. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS spectroscopic analyses. Compound 1 displayed anticancer activity against HCT-116 colon...

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Bibliographic Details
Published in:Journal of asian natural products research 2020-05, Vol.22 (5), p.474-488
Main Authors: Fadaeinasab, Mehran, Karimian, Hamed, Omar, Hanita, Taha, Hairin, khorasani, Arash, Banisalam, Behrooz, Aziz Ketuly, Kamal, Abdullah, Zanariah
Format: Article
Language:English
Subjects:
Acute toxicity
Anticancer properties
Antitumor activity
Apoptosis
Bark
Biocompatibility
Colon
Colon cancer
Colonic Neoplasms
Colorectal cancer
Flavanones
HCT-116 cells
Humans
In vivo methods and tests
Indole Alkaloids
Indoles
Molecular Structure
NMR
Nuclear magnetic resonance
Rauvolfia
Rauvolfia reflexa
Rauwolfia
reflexin A
Toxicity
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Summary:One new indole alkaloid, reflexin A (1), and two known indoles, macusine B (2) and vinorine (3), were isolated from the bark of Rauvolfia reflexa. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS spectroscopic analyses. Compound 1 displayed anticancer activity against HCT-116 colon cancer cells with an IC 50 value of 30.24 ± 0.75 µM. The results implied that the newly isolated 1 induced apoptosis in HCT-116 cells, suggesting its possible role as an anticancer agent. In vivo acute toxicity study was performed on compound 1 to evaluate its safety profile.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2019.1588888