Anxiolytic Activity of 11H-2,3,4,5-Tetrahydro[1,3]Diazepino[1,2-a]Benzimidazole and 2-Mercaptobenzimizadole Derivatives

— This paper presents a study of the anxiolytic activity of compounds that belong to two classes of chemical groups: derivatives of 11 H -2,3,4,5-tetrahydro[1,3]diazepino[1,2- a ]benzimidazole (BIF) and derivatives of 2-mercaptobenzimidazole (AZH). The study has revealed that the studied compounds e...

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Bibliographic Details
Published in:Russian journal of bioorganic chemistry 2020, Vol.46 (1), p.107-114
Main Authors: Spasov, A. A., Zhukovskaya, O. N., Maltsev, D. V., Miroshnikov, M. V., Skripka, M. O., Sultanova, K. T., Morkovnik, A. S.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Derivatives
Life Sciences
Mercaptobenzimidazole
Organic Chemistry
Psychotropic drugs
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Summary:— This paper presents a study of the anxiolytic activity of compounds that belong to two classes of chemical groups: derivatives of 11 H -2,3,4,5-tetrahydro[1,3]diazepino[1,2- a ]benzimidazole (BIF) and derivatives of 2-mercaptobenzimidazole (AZH). The study has revealed that the studied compounds exhibit different degrees of tranquilizing action. The most potent anxiolytics were compounds BIF-66 and AZH-57. These compounds hold promise for an in-depth study of their neuropsychotropic profile.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162020010124