Alpha-mangostin reduces mechanical stiffness of various cells

Alpha-mangostin (α-mangostin) has been identified as a naturally occurring compound with potential anticancer properties. It can induce apoptosis and inhibit the growth and metastasis of cancer cells. Moreover, α-mangostin reduces the mechanical stiffness of lung cancer cells. The objective of this...

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Bibliographic Details
Published in:Human cell : official journal of Human Cell Research Society 2020-04, Vol.33 (2), p.347-355
Main Authors: Phan, Thi Kieu Trang, Shahbazzadeh, Fahimeh, Kihara, Takanori
Format: Article
Language:English
Subjects:
Actin
Apoptosis
Atomic force microscopy
Biomedical and Life Sciences
Cell Biology
Cell viability
Cytoskeleton
Cytotoxicity
Gynecology
Life Sciences
Lung cancer
Macrophages
Metastases
Oncology
Reproductive Medicine
Research Article
Stem Cells
Surgery
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Summary:Alpha-mangostin (α-mangostin) has been identified as a naturally occurring compound with potential anticancer properties. It can induce apoptosis and inhibit the growth and metastasis of cancer cells. Moreover, α-mangostin reduces the mechanical stiffness of lung cancer cells. The objective of this study was to determine the effect of α-mangostin on the mechanical stiffness of various cells, as well as cell viability. The following cell types were examined: human fibroblast TIG-1 cells, human cancerous HeLa cells, human embryonic kidney HEK293 cells, mouse macrophage RAW 264.7 cells, and human myeloblasts KG-1 cells. Cells were treated with α-mangostin, and then examined for cell viability, actin cytoskeletal structures, and surface mechanical stiffness using atomic force microscopy. α-Mangostin demonstrated cytotoxicity against TIG-1, HeLa, HEK293, and KG-1 cells, but not against RAW 264.7 cells. The cytotoxic effect of α-mangostin varies according to cell type. On the other hand, α-mangostin reduced the mechanical stiffness of all cell types, including RAW 264.7 cells. Upon treatment with α-mangostin, F-actin was slightly reduced but the actin cytoskeletal structures were little altered in these cells. Thus, reducing mechanical stiffness of animal cells is an inherent effect of α-mangostin. Our results show that α-mangostin is a naturally occurring compound with potential to change the actin cytoskeletal micro-structures and reduce the surface stiffness of various cells.
ISSN:0914-7470
1749-0774
DOI:10.1007/s13577-020-00330-0