TOXICITY OF CONCURRENT CHEMORADIATION IN LOCALLY ADVANCED RECTAL CARCINOMA

ABSTRACT Objective: To evaluate treatment related toxicity of concurrent chemoradiation in locally advanced rectal carcinoma Study Design: Cross sectional study. Place and Duration of Study: Department of Oncology, Combined Military Hospital (CMH), Rawalpindi, from Jan 2017 to Jul 2017. Methodology:...

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Bibliographic Details
Published in:Pakistan Armed Forces medical journal 2020-02 (1), p.S122
Main Authors: Tareen, Meherullah, Ahsan Mahmood, Tareen, Siafullah, Muhammad Yousaf Khan
Format: Article
Language:English
Subjects:
Age
Anemia
Cancer therapies
Cancer treatment
Capecitabine
Carcinoma
Chemotherapy
Colorectal cancer
Complications and side effects
Conflicts of interest
Dermatitis
Diarrhea
Diseases
Drug dosages
Enzymes
Females
Hematology
Neutropenia
Obesity
Oncology
Patients
Radiation (Physics)
Radiation therapy
Radiotherapy
Surgery
Toxicity
Vomiting
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Summary:ABSTRACT Objective: To evaluate treatment related toxicity of concurrent chemoradiation in locally advanced rectal carcinoma Study Design: Cross sectional study. Place and Duration of Study: Department of Oncology, Combined Military Hospital (CMH), Rawalpindi, from Jan 2017 to Jul 2017. Methodology: Thirty-five patients with histopathologically diagnosed T3-4, N0-2, M0 adenocarcinoma rectum requiring neo adjuvant concurrent chemoradiation delivered using 3-D conformal technique with high-energy photon beams to were included. Patients were followed up weekly during concurrent chemoradiation to evaluate for any adverse events. Results: Out of total 35 patient, only grade 3 radiation dermatitis developed in two patients. Grade 2 hematological toxicities i.e. anemia, leucocytopenia and neutropenia were noted in 11.4%, 17.14% and 5.71% of the patients, respectively. While grade 2 non-hematological toxicities including diarrhea, nausea, vomiting and radiation dermatitis were observed in 17.14%, 2.85%, 2.85% and 20% respectively. Grade 1 hematological toxicities i.e. anemia, leucocytopenia and thrombocytopenia were noted in 7 (20%), 12 (34.28%) and 6 (17.14%) of the patients, respectively. Conclusion: Concurrent chemoradiation along with oral chemotherapy capecitabine in neoadjuvant setting was a well-tolerated and acceptable treatment option for locally advanced carcinoma of rectum.
ISSN:0030-9648
2411-8842