Malignant mesothelioma in situ diagnosed by methylthioadenosine phosphorylase loss and homozygous deletion of CDKN2A: a case report

Malignant pleural mesothelioma (MPM), associated with unfavorable outcomes, is closely associated with asbestos exposure. Early detection and treatment are critical to prolong survival of patients with MPM because of the rapid progression and resistance to treatment. The recently defined malignant m...

Full description

Saved in:
Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2020-03, Vol.476 (3), p.469-473
Main Authors: Minami, Kazuhiro, Jimbo, Naoe, Tanaka, Yugo, Hokka, Daisuke, Miyamoto, Yoshifumi, Itoh, Tomoo, Maniwa, Yoshimasa
Format: Article
Language:English
Subjects:
5'-Methylthioadenosine phosphorylase
Aged
Asbestos
Biomarkers, Tumor - analysis
Biopsy
Brief Report
Case reports
Clonal deletion
Cyclin-Dependent Kinase Inhibitor p16 - analysis
Cyclin-Dependent Kinase Inhibitor p16 - genetics
Early Diagnosis
Fluorescence
Fluorescence in situ hybridization
Gene deletion
Genes, p16
Genomes
Humans
Immunohistochemistry
Lung Neoplasms - diagnosis
Male
Medicine
Medicine & Public Health
Mesothelioma
Mesothelioma - diagnosis
Mesothelioma, Malignant
Pathology
Phosphorylase
Phosphorylases
Pleural effusion
Pleural Neoplasms - diagnosis
Purine-Nucleoside Phosphorylase - analysis
Purine-Nucleoside Phosphorylase - biosynthesis
Quality in Pathology
Sequence Deletion
Surgery
Thorax
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Malignant pleural mesothelioma (MPM), associated with unfavorable outcomes, is closely associated with asbestos exposure. Early detection and treatment are critical to prolong survival of patients with MPM because of the rapid progression and resistance to treatment. The recently defined malignant mesothelioma in situ (MIS) has been gaining increasing attention with advances in genome-based methods including fluorescence in situ hybridization (FISH) as well as immunohistochemistry. We herein report the case of a MIS in a 73-year-old male with a history of asbestos exposure presenting with massive pleural effusion in the right thoracic cavity. Video-assisted thoracoscopic surgery with pleural biopsy of the right side revealed a single layer of atypical mesothelial cells without invasive lesions by hematoxylin and eosin staining. However, these mesothelial cells exhibited a loss of methylthioadenosine phosphorylase (MTAP) by immunohistochemistry and homozygous deletion of CDKN2A ( p16 ) by FISH, leading to the diagnosis of MIS.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-019-02674-x