Radiosynthesis and Bioevaluation of Ranitidine as Highly Selective Radiotracer for Peptic Ulcer Disorder Detection

Ranitidine was labeled with [ 125 I] or [ 131 I] with N -bromosuccinimide (NBS) and chloramine-T (Ch-T) as oxidizing agents. The substrate amount, pH of reaction medium, reaction time, and oxidizing agent were varied to find the optimum radiolabeling conditions ensuring 97% yield of [ 125 I]iodorani...

Full description

Saved in:
Bibliographic Details
Published in:Radiochemistry (New York, N.Y.) N.Y.), 2020, Vol.62 (1), p.119-124
Main Authors: Sanad, M. H., Rizvi, F. A., Kumar, R. R.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Nuclear Chemistry
Oxidation
Oxidizing agents
Peptic ulcers
Radioactive tracers
Radiolabelling
Ranitidine
Reaction time
Substrates
Ulcers
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ranitidine was labeled with [ 125 I] or [ 131 I] with N -bromosuccinimide (NBS) and chloramine-T (Ch-T) as oxidizing agents. The substrate amount, pH of reaction medium, reaction time, and oxidizing agent were varied to find the optimum radiolabeling conditions ensuring 97% yield of [ 125 I]iodoranitidine. Biodistribution studies demonstrate the suitability of [ 125 I]iodoranitidine as a novel tracer to image stomach ulcer.
ISSN:1066-3622
1608-3288
DOI:10.1134/S1066362220010154