5PSQ-002 Hypomagnesaemia alert! Monitor closely proton pump inhibitors for chronic treatment in elderly patients

Background and importanceThere have only been 175 cases of hypomagnesaemia associated with prolonged use of proton pump inhibitors (PPIs) reported to FEDRA (Spanish Pharmacovigilance, Adverse Reaction Data) since commercialisation of PPIs, despite the alert published by AEMPS in 2011.Aim and objecti...

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Published in:European journal of hospital pharmacy. Science and practice 2020-03, Vol.27 (Suppl 1), p.A150-A150
Main Authors: Dominguez Barahona, A, Gonzalez Suarez, S, Martinez Camacho, M, Rodriguez Jimenez, E, Alonso Seco, M, Santos Azorín, A, López Álvarez, R, Toledo Davia, MA, García Marco, D
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Diuretics
Electrolytes
Geriatrics
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container_title European journal of hospital pharmacy. Science and practice
container_volume 27
creator Dominguez Barahona, A
Gonzalez Suarez, S
Martinez Camacho, M
Rodriguez Jimenez, E
Alonso Seco, M
Santos Azorín, A
López Álvarez, R
Toledo Davia, MA
García Marco, D
description Background and importanceThere have only been 175 cases of hypomagnesaemia associated with prolonged use of proton pump inhibitors (PPIs) reported to FEDRA (Spanish Pharmacovigilance, Adverse Reaction Data) since commercialisation of PPIs, despite the alert published by AEMPS in 2011.Aim and objectivesTo detect hypomagnesaemia in patients admitted to an acute geriatric hospital and look for a relationship with chronic PPI treatment, and to determine the frequency of this adverse effect with respect to all hospitalised patients and the electrolyte alterations that may be related.Material and methodsA retrospective study was conducted during the first half of 2019 in admitted patients treated with magnesium in an acute geriatric 160 bed hospital. Demographic data were collected (age, sex). Hypomagnesaemia (
doi_str_mv 10.1136/ejhpharm-2020-eahpconf.319
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Monitor closely proton pump inhibitors for chronic treatment in elderly patients</title><source>PubMed Central</source><creator>Dominguez Barahona, A ; Gonzalez Suarez, S ; Martinez Camacho, M ; Rodriguez Jimenez, E ; Alonso Seco, M ; Santos Azorín, A ; López Álvarez, R ; Toledo Davia, MA ; García Marco, D</creator><creatorcontrib>Dominguez Barahona, A ; Gonzalez Suarez, S ; Martinez Camacho, M ; Rodriguez Jimenez, E ; Alonso Seco, M ; Santos Azorín, A ; López Álvarez, R ; Toledo Davia, MA ; García Marco, D</creatorcontrib><description>Background and importanceThere have only been 175 cases of hypomagnesaemia associated with prolonged use of proton pump inhibitors (PPIs) reported to FEDRA (Spanish Pharmacovigilance, Adverse Reaction Data) since commercialisation of PPIs, despite the alert published by AEMPS in 2011.Aim and objectivesTo detect hypomagnesaemia in patients admitted to an acute geriatric hospital and look for a relationship with chronic PPI treatment, and to determine the frequency of this adverse effect with respect to all hospitalised patients and the electrolyte alterations that may be related.Material and methodsA retrospective study was conducted during the first half of 2019 in admitted patients treated with magnesium in an acute geriatric 160 bed hospital. Demographic data were collected (age, sex). Hypomagnesaemia (&lt;1.9 mg/dL) associated with chronic PPI treatment was reviewed, and risk factors such as concomitant treatment with loop diuretics and/or thiazide diuretics, and/or potentially related electrolyte alterations (hypokalaemia (&lt;3.7 mEq/l) and hypocalcaemia (&lt;8.4 mg/dL)) were assessed. The frequency of the adverse event was determined from the total number of patients admitted receiving treatment with PPIs.ResultsThere were 67 patients receiving magnesium treatment and 5 were excluded as it was unrelated to PPI treatment. The included patients had a mean age of 83.96 years (26 men and 36 women) and had been receiving PPI treatment for a mean of 9.17 years. Forty-nine patients (79.03%) received concomitantly a diuretic. In 12 patients (19.35%) clinically significant low magnesium levels were found (&lt; 1.2 mg/dL), 6 of them (9.67%) critical (&lt;0.9 mg/dL). We recorded14 patients (22.58%) with hypokalaemia and 11 (17.74%) with hypocalcaemia.Of the 2301 admitted patients, 1960 were being treated with a PPI (85.18%) and hence the frequency of hypomagnesaemia related to PPIs in our study population was 1/31 patients treated. FEDRA will be notified of these results. In 41 (66.12%) there was a change in treatment: 35 (56.45%) switched to ranitidine and in 6 (9.67%) the PPI was discontinued.Conclusion and relevanceIn our study, hypomagnesaemia was a frequent adverse effect (≥1/100 to ≤1/10). This adverse effect was underrated, which means that it is still considered infrequent. We believe that more studies are needed that can quantify the frequency within the patient‘s healthcare continuity.References and/or acknowledgementshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230950/No conflict of interest.</description><identifier>ISSN: 2047-9956</identifier><identifier>EISSN: 2047-9964</identifier><identifier>DOI: 10.1136/ejhpharm-2020-eahpconf.319</identifier><language>eng</language><publisher>London: BMJ Publishing Group LTD</publisher><subject>Diuretics ; Electrolytes ; Geriatrics</subject><ispartof>European journal of hospital pharmacy. Science and practice, 2020-03, Vol.27 (Suppl 1), p.A150-A150</ispartof><rights>Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2020 Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids></links><search><creatorcontrib>Dominguez Barahona, A</creatorcontrib><creatorcontrib>Gonzalez Suarez, S</creatorcontrib><creatorcontrib>Martinez Camacho, M</creatorcontrib><creatorcontrib>Rodriguez Jimenez, E</creatorcontrib><creatorcontrib>Alonso Seco, M</creatorcontrib><creatorcontrib>Santos Azorín, A</creatorcontrib><creatorcontrib>López Álvarez, R</creatorcontrib><creatorcontrib>Toledo Davia, MA</creatorcontrib><creatorcontrib>García Marco, D</creatorcontrib><title>5PSQ-002 Hypomagnesaemia alert! Monitor closely proton pump inhibitors for chronic treatment in elderly patients</title><title>European journal of hospital pharmacy. Science and practice</title><description>Background and importanceThere have only been 175 cases of hypomagnesaemia associated with prolonged use of proton pump inhibitors (PPIs) reported to FEDRA (Spanish Pharmacovigilance, Adverse Reaction Data) since commercialisation of PPIs, despite the alert published by AEMPS in 2011.Aim and objectivesTo detect hypomagnesaemia in patients admitted to an acute geriatric hospital and look for a relationship with chronic PPI treatment, and to determine the frequency of this adverse effect with respect to all hospitalised patients and the electrolyte alterations that may be related.Material and methodsA retrospective study was conducted during the first half of 2019 in admitted patients treated with magnesium in an acute geriatric 160 bed hospital. Demographic data were collected (age, sex). Hypomagnesaemia (&lt;1.9 mg/dL) associated with chronic PPI treatment was reviewed, and risk factors such as concomitant treatment with loop diuretics and/or thiazide diuretics, and/or potentially related electrolyte alterations (hypokalaemia (&lt;3.7 mEq/l) and hypocalcaemia (&lt;8.4 mg/dL)) were assessed. The frequency of the adverse event was determined from the total number of patients admitted receiving treatment with PPIs.ResultsThere were 67 patients receiving magnesium treatment and 5 were excluded as it was unrelated to PPI treatment. The included patients had a mean age of 83.96 years (26 men and 36 women) and had been receiving PPI treatment for a mean of 9.17 years. Forty-nine patients (79.03%) received concomitantly a diuretic. In 12 patients (19.35%) clinically significant low magnesium levels were found (&lt; 1.2 mg/dL), 6 of them (9.67%) critical (&lt;0.9 mg/dL). We recorded14 patients (22.58%) with hypokalaemia and 11 (17.74%) with hypocalcaemia.Of the 2301 admitted patients, 1960 were being treated with a PPI (85.18%) and hence the frequency of hypomagnesaemia related to PPIs in our study population was 1/31 patients treated. FEDRA will be notified of these results. In 41 (66.12%) there was a change in treatment: 35 (56.45%) switched to ranitidine and in 6 (9.67%) the PPI was discontinued.Conclusion and relevanceIn our study, hypomagnesaemia was a frequent adverse effect (≥1/100 to ≤1/10). This adverse effect was underrated, which means that it is still considered infrequent. We believe that more studies are needed that can quantify the frequency within the patient‘s healthcare continuity.References and/or acknowledgementshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230950/No conflict of interest.</description><subject>Diuretics</subject><subject>Electrolytes</subject><subject>Geriatrics</subject><issn>2047-9956</issn><issn>2047-9964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNo9kMlOwzAQQC0EElXpPxg4B7xksY-oAopUBAg4W5PEJqmSONjuoTcu_ChfgqNSTjOaebPoIXRByRWlPL_Wm2ZswPUJI4wkGpqxsoO54lQeoRkjaZFImafH_3mWn6KF921JMs6FTLmcIZc9v74khLCfr-_VbrQ9fAzag-5bwNBpF87xox3aYB2uOut1t8Ojs8EOeNz2I26Hpi2nrsdmQhoX4QoHpyH0eggRwLqrtZvmILSx5M_QiYHO68VfnKP3u9u35SpZP90_LG_WSUlZLpMUdJ0xVtBU1HVRCkaoAVGxvAAWy1VaGiPrAipjKCkg14KIWmhBSVpBwTM-R5f7vfHhz632QW3s1g3xpGJcMMkzIliksj1V9hs1urYHt1OUqMmwOhhWk2F1MKyiYf4LL6l2rg</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Dominguez Barahona, A</creator><creator>Gonzalez Suarez, S</creator><creator>Martinez Camacho, M</creator><creator>Rodriguez Jimenez, E</creator><creator>Alonso Seco, M</creator><creator>Santos Azorín, A</creator><creator>López Álvarez, R</creator><creator>Toledo Davia, MA</creator><creator>García Marco, D</creator><general>BMJ Publishing Group LTD</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>202003</creationdate><title>5PSQ-002 Hypomagnesaemia alert! Monitor closely proton pump inhibitors for chronic treatment in elderly patients</title><author>Dominguez Barahona, A ; Gonzalez Suarez, S ; Martinez Camacho, M ; Rodriguez Jimenez, E ; Alonso Seco, M ; Santos Azorín, A ; López Álvarez, R ; Toledo Davia, MA ; García Marco, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b1269-4aed5227148dd7b8201fa8c267a2227c4bff9d7acff107a6e808d8e8104ca7353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Diuretics</topic><topic>Electrolytes</topic><topic>Geriatrics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dominguez Barahona, A</creatorcontrib><creatorcontrib>Gonzalez Suarez, S</creatorcontrib><creatorcontrib>Martinez Camacho, M</creatorcontrib><creatorcontrib>Rodriguez Jimenez, E</creatorcontrib><creatorcontrib>Alonso Seco, M</creatorcontrib><creatorcontrib>Santos Azorín, A</creatorcontrib><creatorcontrib>López Álvarez, R</creatorcontrib><creatorcontrib>Toledo Davia, MA</creatorcontrib><creatorcontrib>García Marco, D</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>European journal of hospital pharmacy. 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Science and practice</jtitle><date>2020-03</date><risdate>2020</risdate><volume>27</volume><issue>Suppl 1</issue><spage>A150</spage><epage>A150</epage><pages>A150-A150</pages><issn>2047-9956</issn><eissn>2047-9964</eissn><abstract>Background and importanceThere have only been 175 cases of hypomagnesaemia associated with prolonged use of proton pump inhibitors (PPIs) reported to FEDRA (Spanish Pharmacovigilance, Adverse Reaction Data) since commercialisation of PPIs, despite the alert published by AEMPS in 2011.Aim and objectivesTo detect hypomagnesaemia in patients admitted to an acute geriatric hospital and look for a relationship with chronic PPI treatment, and to determine the frequency of this adverse effect with respect to all hospitalised patients and the electrolyte alterations that may be related.Material and methodsA retrospective study was conducted during the first half of 2019 in admitted patients treated with magnesium in an acute geriatric 160 bed hospital. Demographic data were collected (age, sex). Hypomagnesaemia (&lt;1.9 mg/dL) associated with chronic PPI treatment was reviewed, and risk factors such as concomitant treatment with loop diuretics and/or thiazide diuretics, and/or potentially related electrolyte alterations (hypokalaemia (&lt;3.7 mEq/l) and hypocalcaemia (&lt;8.4 mg/dL)) were assessed. The frequency of the adverse event was determined from the total number of patients admitted receiving treatment with PPIs.ResultsThere were 67 patients receiving magnesium treatment and 5 were excluded as it was unrelated to PPI treatment. The included patients had a mean age of 83.96 years (26 men and 36 women) and had been receiving PPI treatment for a mean of 9.17 years. Forty-nine patients (79.03%) received concomitantly a diuretic. In 12 patients (19.35%) clinically significant low magnesium levels were found (&lt; 1.2 mg/dL), 6 of them (9.67%) critical (&lt;0.9 mg/dL). We recorded14 patients (22.58%) with hypokalaemia and 11 (17.74%) with hypocalcaemia.Of the 2301 admitted patients, 1960 were being treated with a PPI (85.18%) and hence the frequency of hypomagnesaemia related to PPIs in our study population was 1/31 patients treated. FEDRA will be notified of these results. In 41 (66.12%) there was a change in treatment: 35 (56.45%) switched to ranitidine and in 6 (9.67%) the PPI was discontinued.Conclusion and relevanceIn our study, hypomagnesaemia was a frequent adverse effect (≥1/100 to ≤1/10). This adverse effect was underrated, which means that it is still considered infrequent. We believe that more studies are needed that can quantify the frequency within the patient‘s healthcare continuity.References and/or acknowledgementshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4230950/No conflict of interest.</abstract><cop>London</cop><pub>BMJ Publishing Group LTD</pub><doi>10.1136/ejhpharm-2020-eahpconf.319</doi><oa>free_for_read</oa></addata></record>
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subjects Diuretics
Electrolytes
Geriatrics
title 5PSQ-002 Hypomagnesaemia alert! Monitor closely proton pump inhibitors for chronic treatment in elderly patients
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