4CPS-018 Efficacy of urea in the treatment of hyponatraemia in syndrome of inappropriate antidiuretic hormone secretion

• Published in: European journal of hospital pharmacy. Science and practice 2020-03, Vol.27 (Suppl 1), p.A55-A55
• Main Authors: Perez, CY, Plasencia García, I, Gómez, MÁ Ocaña, Ferrer Machín, A, Álvarez Tosco, K, Merino Alonso, J, Díaz Díaz, L, González García, I, Mesa Expósito, R, Tévar Alfonso, E, Vera Cabrera, M
• Format: Article
• Language: English
• Subjects: Sodium
• ISSN: 2047-9956; 2047-9964
• DOI: 10.1136/ejhpharm-2020-eahpconf.119

Background and importanceThe consequence of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a hypotonic hyponatraemia. Urea is a well tolerated therapeutic option indicated to correct sodium levels, acting as an osmotic diuretic, eliminating a large amount of water in urine accompanied by an increase in plasma sodium concentration.Aim and objectivesTo evaluate the efficacy of urea in controlling hypernatraemia due to SIADH in a third level hospital.Material and methodsThis was a quasi-experimental study. Patients with hyponatraemia treated with urea in 2019 were included.The main variable of our study was serum sodium level before treatment with urea at 24 hours, 48 hours, 14 days and 60 days. Age and sex were included as secondary variables.There were no extreme outliers and the data were normally distributed for each measured time, as assessed by box plot and the Shapiro–Wilk test (p>0.05), respectively. A one-way repeated measures ANOVA was conducted to determine whether there was a statistically significant difference in sodium concentration before and after treatment with urea. The analyses were performed using the SPSS/PC statistical programme (V.24.0 for Windows, SPSS Inc, Chicago, Illinois, USA).ResultsThirty-three patients were treated with urea for 9 months. Of these, 67% were men and mean age was 77±13 years. Serum sodium levels before treatment and at 24 hours, 48 hours, 14 days and 60 days were 125±4, 127±5, 129±5, 134±4 and 134±4 mg/dL respectively. Time did not elicit statistically significant changes in sodium levels before and after treatment with urea (F=4.1, p=0.074).Conclusion and relevanceIn the study, there were no significant differences in plasma sodium values before and after urea treatment, so we did not demonstrate the efficacy of urea. The main drawback in the study was the small population analysed.References and/or acknowledgementsNo conflict of interest.