Synthesis, Crystal Structure, and DNA Binding Studies of the 3-(2-(2-Hydroxybenzylidene)Hydrazinyl)Quinoxalin-2(1H)-One

— The Schiff base, 3-(2-(2-hydroxybenzylidene)hydrazinyl)quinoxalin-2(1H)-one has been synthesized by condensation of 3-hydrazinyl quinoxalin-2(1H)-one and salicylaldehyde and characterized by infrared and ultraviolet–visible spectroscopy, 1 H NMR, mass spectrometry, elemental analysis, and single c...

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Bibliographic Details
Published in:Crystallography reports 2020, Vol.65 (1), p.72-77
Main Authors: Sukanya, P., Reddy, Ch. Venkata Ramana, Bhargavi, G.
Format: Article
Language:English
Subjects:
Binding
Chemical bonds
Crystal structure
Crystallography and Scattering Methods
Hydrogen bonds
Imines
Infrared analysis
Mass spectrometry
NMR
Nuclear magnetic resonance
Physics
Physics and Astronomy
Single crystals
Structure of Organic Compounds
Ultraviolet spectroscopy
Unit cell
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Summary:— The Schiff base, 3-(2-(2-hydroxybenzylidene)hydrazinyl)quinoxalin-2(1H)-one has been synthesized by condensation of 3-hydrazinyl quinoxalin-2(1H)-one and salicylaldehyde and characterized by infrared and ultraviolet–visible spectroscopy, 1 H NMR, mass spectrometry, elemental analysis, and single crystal X-ray diffraction. The compound crystallizes in the monoclinic system in the space group P 2 1 / n with the unit cell parameters a = 5.8619(15) Å, b = 24.119(6) Å, c = 12.753(4) Å, β = 100.184(9)°, Z = 4. The crystal structure is found to be stabilized through inter-molecular hydrogen bonds. The interaction of the compound with Calf Thymus DNA was investigated by ultraviolet spectroscopy, which indicated intercalative mode of binding.
ISSN:1063-7745
1562-689X
DOI:10.1134/S1063774520010253