Clinicopathological association of p16 and its impact on outcome of chemoradiation in head-and-neck squamous cell cancer patients in North-East India

Purpose: Human papillomavirus-associated head-and-neck squamous cell cancer (HNSCC) is following an increasing trend in Western countries, which has unique biology and confers better prognosis, whereas there are limited data from Indian studies in this context. Methods: We conducted a prospective co...

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Bibliographic Details
Published in:Cancer translational medicine 2020-01, Vol.6 (1), p.10-16
Main Authors: Mohanty, Srigopal, Devi, Yumkhaibam, Daniel, Nithin, Ponna, Dulasi, Devi, Madhubala, Singh, Laishram
Format: Article
Language:English
Subjects:
Age
Alcoholism
Apoptosis
Cancer therapies
Cell cycle
Confidence intervals
Cyclin-dependent kinases
Cytoplasm
Deoxyribonucleic acid
DNA
Human papillomavirus
Infections
Multivariate analysis
Patients
Population
Radiation therapy
Tobacco
Tumors
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Summary:Purpose: Human papillomavirus-associated head-and-neck squamous cell cancer (HNSCC) is following an increasing trend in Western countries, which has unique biology and confers better prognosis, whereas there are limited data from Indian studies in this context. Methods: We conducted a prospective cohort study to evaluate the clinicopathological association of p16 in locally advanced HNSCC and its impact on outcome of chemoradiation. The study population was divided into two arms; p16-positive and p16-negative arms. All patients were treated with concurrent chemoradiation using weekly cisplatin. Statistical Analysis Used: SPSS version 21 for Windows was used for statistical analysis. Chi-square test and multivariate analysis were performed to evaluate different association and impact of p16. P
ISSN:2395-3977
2395-3012
DOI:10.4103/ctm.ctm_34_19