Three Modalities of Synaptic Neurotransmitter Release: Rapid Synchronized, Multivesicular, and Asynchronous. Similarities and Differences in Mechanisms

The central nervous system contains several modalities for neurotransmitter release: phasic (synchronous), asynchronous, and multivesicular. This review summarizes results from studies in recent years demonstrating the involvement of different calcium sensors in triggering synchronous and asynchrono...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 2020, Vol.50 (1), p.102-108
Main Authors: Valiullina-Rakhmatullina, F. F., Bolshakov, A. P., Rozov, A. V.
Format: Article
Language:English
Subjects:
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Calcium
Central nervous system
Neurobiology
Neurosciences
Neurotransmitter release
Neurotransmitters
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Summary:The central nervous system contains several modalities for neurotransmitter release: phasic (synchronous), asynchronous, and multivesicular. This review summarizes results from studies in recent years demonstrating the involvement of different calcium sensors in triggering synchronous and asynchronous neurotransmitter release. In addition, the possible sources of presynaptic Ca 2+ triggering asynchronous neurotransmitter release are considered, along with the possible mechanisms of multivesicular neurotransmitter release.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-019-00874-1