Synthesis and Anticancer Activity of a Novel Series of Tetrazolo[1,5-a]quinoline Based 1,2,3-Triazole Derivatives

We report here the synthesis of a novel series of tetrazolo[1,5- a ]quinoline based 1,2,3-triazoles from acetaniline via the Vilsmeier–Haack reaction, the Claisen–Schmidt condensation and 1,3-dipolar Click reaction. The newly synthesized compounds have been tested for their anticancer activity again...

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Bibliographic Details
Published in:Russian journal of general chemistry 2020-02, Vol.90 (2), p.314-318
Main Authors: Nagaraju, R., Gopichand, K., Rao, N. N., Ganai, A. M., Kishan, E., Rao, P. Venkateswar
Format: Article
Language:English
Subjects:
Anticancer properties
Cancer
Care and treatment
Chemical reactions
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Drug therapy
Pancreatic cancer
Quinoline
Triazoles
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Summary:We report here the synthesis of a novel series of tetrazolo[1,5- a ]quinoline based 1,2,3-triazoles from acetaniline via the Vilsmeier–Haack reaction, the Claisen–Schmidt condensation and 1,3-dipolar Click reaction. The newly synthesized compounds have been tested for their anticancer activity against a panel of three cell lines such as cervix (SiHa), brest (MDA-MB-231) and pancreatic carcinoma (PANC-1). Most of the synthesized compounds possess potent anticancer activity.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363220020255