Severe bronchoconstriction as part of a suspected anaphylactic reaction in a dog following administration of gadobutrol

A four-year-and-three-month-old Jack Russell terrier presented for investigation of acute-onset paraplegia, with an MRI performed under general anaesthesia. Following administration of a gadobutrol contrast medium, apnoea, cyanosis, resistance to ventilation, hypotension and tachycardia were observe...

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Bibliographic Details
Published in:Veterinary record case reports 2020-06, Vol.8 (2), p.n/a
Main Authors: Tucker, Philippa Kate, Macfarlane, Paul
Format: Article
Language:English
Subjects:
anaesthesia
anaphylaxis
Anesthesia
Blood pressure
bronchoconstriction
Cardiac arrhythmia
Case reports
Catheters
continuous positive airway pressure
gadolinium
Immunology
Investigations
Paralysis
Veins & arteries
Ventilators
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Summary:A four-year-and-three-month-old Jack Russell terrier presented for investigation of acute-onset paraplegia, with an MRI performed under general anaesthesia. Following administration of a gadobutrol contrast medium, apnoea, cyanosis, resistance to ventilation, hypotension and tachycardia were observed. An anaphylactic reaction was suspected, characterised by severe bronchoconstriction and cardiovascular collapse. This was treated with multiple isotonic crystalloid fluid boluses, intermittent positive pressure ventilation, terbutaline and cessation of general anaesthesia. Following recovery from general anaesthesia, continuous positive airway pressure and later high-flow nasal oxygen therapy were needed to treat severe hypoxaemia. Treatment of the acute anaphylactic reaction was successful; however, the dog was euthanased due to progressive neurological disease.
ISSN:2052-6121
2052-6121
DOI:10.1136/vetreccr-2019-001051