FOLLICULAR DENDRITIC CELLS IN MAMMALS – AN OVERVIEW

Dendritic cells (DCs) are antigen-presenting cells. They recognize antigens and can present these antigens to naïve T lymphocytes. DCs play an important part in the mechanism of adaptive immunity. Namely, they control and regulate adaptive immune responses. DCs secrete cytokines involved in the remo...

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Bibliographic Details
Published in:Journal of microbiology, biotechnology and food sciences biotechnology and food sciences, 2020-04, Vol.9 (5), p.946-948
Main Authors: Kratochvílová, Lucie, Sláma, Petr
Format: Article
Language:English
Subjects:
Adaptive control
Adaptive immunity
Antigen-presenting cells
Antigens
Cytokines
Dendritic cells
Dendritic structure
Follicles
Immune response
Immune response (humoral)
Immune system
Immunity
Immunity (Disease)
Lymph nodes
Lymphocytes
Lymphocytes B
Lymphocytes T
Mammals
Mucosa
Spleen
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Summary:Dendritic cells (DCs) are antigen-presenting cells. They recognize antigens and can present these antigens to naïve T lymphocytes. DCs play an important part in the mechanism of adaptive immunity. Namely, they control and regulate adaptive immune responses. DCs secrete cytokines involved in the removal of pathogenic agents. They represent the boundary between innate and adaptive immunity. We can see these cells in lymph nodes, spleen, mucosa and other parts of a body in mammals. Several kinds of dendritic cells differ in positions, structure and functions. One type of DCs is follicular dendritic cells (FDCs). FDCs are located in lymphoid follicles in mammals. FDCs have the main role in binding and retaining antigens by linking to complexes (mainly complement and immune). After they present these pathogenic agents to the germinal center (GC) of B lymphocytes and initiate the secondary immune response. FDCs as well as other DCs play an important part in effective humoral response towards pathogenic agents. Most studies about FDCs are in human and mice and there is a lack of studies that concentrate on bovine follicular dendritic cells (BFDCs). This review provides a brief overview of FDCs in mammals.
ISSN:1338-5178
1338-5178
DOI:10.15414/jmbfs.2020.9.5.946-948