Ruthenium‐Catalyzed meta‐CAr–H Bond Difluoroalkylation of 2‐Phenoxypyridines

A ruthenium‐catalyzed meta‐selective CAr–H bond difluoroalkylation of 2‐phenoxypyridine using 2‐bromo‐2,2‐difluoroacetate has been developed. Mechanistic studies indicated that this difluoroalkylation might involve a radical process. Furthermore, a new method is reported for the synthesis of 2‐(meta...

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Bibliographic Details
Published in:European journal of organic chemistry 2020-04, Vol.2020 (13), p.1992-1995
Main Authors: Jia, Chunqi, Wang, Shichong, Lv, Xulu, Li, Gang, Zhong, Lei, Zou, Lei, Cui, Xiuling
Format: Article
Language:English
Subjects:
C–H activation
Difluoroalkylation
Hydrogen bonds
meta‐CAr–H
Phenoxypyridine
Ruthenium
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Summary:A ruthenium‐catalyzed meta‐selective CAr–H bond difluoroalkylation of 2‐phenoxypyridine using 2‐bromo‐2,2‐difluoroacetate has been developed. Mechanistic studies indicated that this difluoroalkylation might involve a radical process. Furthermore, a new method is reported for the synthesis of 2‐(meta‐difluoroalkylphenoxy)pyridine derivatives, which are present in many pharmaceuticals and other functional compounds. A ruthenium‐catalyzed meta‐selective CAr–H bond difluoroalkylation of 2‐phenoxypyridine using 2‐bromo‐2,2‐difluoroacetate has been developed, which provide a new method to synthesize 2‐(meta‐difluoroalkylphenoxy)pyridine derivatives, which are present in many pharmaceuticals and other functional compounds.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201901883