Rabbit anti-thymocyte globulin (rATG) versus IL-2 receptor antagonist induction therapies in tacrolimus-based immunosuppression era: a meta-analysis

Background The aim of this meta-analysis is to explore the effect of IL-2RA vs rATG on the rate of acute rejection, post-transplant infections, and graft as well as patient’s survival in standard- and high-risk renal transplant patients receiving tacrolimus-based maintenance immunotherapy. Methods R...

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Bibliographic Details
Published in:International urology and nephrology 2020-04, Vol.52 (4), p.791-802
Main Authors: Ali, Hatem, Soliman, Karim M., Shaheen, Ihab, Kim, Jon Jin, Kossi, Mohsen El, Sharma, Ajay, Pararajasingam, Ravi, Halawa, Ahmed
Format: Article
Language:English
Subjects:
Antilymphocyte Serum - adverse effects
Antilymphocyte Serum - therapeutic use
Basiliximab - therapeutic use
Cytomegalovirus
Cytomegalovirus Infections - chemically induced
Daclizumab - therapeutic use
Globulins
Graft rejection
Graft Rejection - prevention & control
Graft Survival
Humans
Immunosuppression
Immunosuppressive Agents - adverse effects
Immunosuppressive Agents - therapeutic use
Immunotherapy
Induction Chemotherapy - methods
Interleukin 2
Interleukin 2 receptors
Kidney Transplantation
Maintenance Chemotherapy
Medicine
Medicine & Public Health
Meta-analysis
Models, Statistical
Nephrology
Nephrology - Original Paper
Receptors, Interleukin-2 - antagonists & inhibitors
Statistical analysis
Survival
Survival Rate
Tacrolimus
Tacrolimus - therapeutic use
Thymocytes
Transplants & implants
Urology
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Summary:Background The aim of this meta-analysis is to explore the effect of IL-2RA vs rATG on the rate of acute rejection, post-transplant infections, and graft as well as patient’s survival in standard- and high-risk renal transplant patients receiving tacrolimus-based maintenance immunotherapy. Methods Random effects model was the method used for identifying risk difference. Confidence interval including the value 1 was used as evidence for statistically significant risk difference. Heterogeneity was assessed using Der Simonian analysis. Heterogeneity was evident at the level of P value 
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-020-02418-w