α‐Iminophosphonates: Useful Intermediates for Enantioselective Synthesis of α‐Aminophosphonates

A wide range of methods for the enantioselective synthesis of α‐aminophosphonic acid derivatives have been developed over the years. Although the most used methodology is the Pudovik reaction, the use of α‐iminophosphonates for the synthesis of optically active α‐aminophosphonates has emerged during...

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Bibliographic Details
Published in:Asian journal of organic chemistry 2020-04, Vol.9 (4), p.538-548
Main Authors: Maestro, Aitor, Marigorta, Edorta Martinez, Palacios, Francisco, Vicario, Javier
Format: Article
Language:English
Subjects:
asymmetric catalysis
Chemical synthesis
Enantiomers
Imines
nucleophilic addition
Optical activity
Organic chemistry
α-aminophosphonates
α-iminophosphonates
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Summary:A wide range of methods for the enantioselective synthesis of α‐aminophosphonic acid derivatives have been developed over the years. Although the most used methodology is the Pudovik reaction, the use of α‐iminophosphonates for the synthesis of optically active α‐aminophosphonates has emerged during the last years. The existing methods for the synthesis of α‐phosphorylated imines and their enantioselective reactions for the synthesis of enantio‐enriched α‐aminophosphonates are summarized in this review. Existing methods for the synthesis of α‐phosphorylated imines and their enantioselective reactions for the synthesis of enantioenriched α‐aminophosphonates are summarized in this review.
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.202000039