Development of a spray-type adhesion barrier

We developed a novel spray-type dextrin hydrogel-based adhesion barrier designed to create a site-specific barrier on a target. Our novel hydrogel is composed of Powder A, which mainly contains N -hydroxysuccinimide-modified carboxymethyl dextrin and trehalose as a stabilizing agent, and Powder B, w...

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Bibliographic Details
Published in:Polymer journal 2020-05, Vol.52 (5), p.473-479
Main Authors: Chino, Naotaka, Ishihara, Hiroyuki, Niimi, Taishi, Kai, Miho, Kawanishi, Tetsuro
Format: Article
Language:English
Subjects:
639/301/930
692/700
Adhesion
Biodegradability
Biomaterials
Bioorganic Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Dextrin
Hydrogels
In vivo methods and tests
Performance evaluation
Polymer Sciences
Product specifications
Sodium bicarbonate
Sodium carbonate
Spraying
Stabilizers (agents)
Surfaces and Interfaces
Technical Review
Thin Films
Trehalose
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Summary:We developed a novel spray-type dextrin hydrogel-based adhesion barrier designed to create a site-specific barrier on a target. Our novel hydrogel is composed of Powder A, which mainly contains N -hydroxysuccinimide-modified carboxymethyl dextrin and trehalose as a stabilizing agent, and Powder B, which is composed of sodium carbonate and sodium hydrogen carbonate. Here, we describe the product specifications of the hydrogel and results of in vivo performance evaluations and clinical studies to demonstrate its efficacy and safety. A novel spray-type dextrin hydrogel-based adhesion barrier is composed of N -hydroxysuccinimide-modified carboxymethyl dextrin that is biodegradable polymer material. The performance evaluation of a spray-type adhesion barrier in porcine laparoscopic model was showed significantly lowered adhesion rate than in the control group ( p  
ISSN:0032-3896
1349-0540
DOI:10.1038/s41428-020-0306-0