Cytotoxic Lathyrane Diterpenoids from the Roots of Euphorbia fischeriana

Two new lathyrane diterpenoids, euphofischers A and B (1 and 2), along with three known analogues (3-5), were isolated from the roots of Euphorbia fischeriana. Their structures were elucidated by spectroscopic analysis. Euphofischer A (1) represents rare example of a lathyrane diterpenoid featuring...

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Bibliographic Details
Published in:Records of natural products 2020-07, Vol.14 (4), p.286-291
Main Authors: Li, Jue, He, Jianlin, Yang, Chunai, Yan, Xuelong, Yin, Zhao
Format: Article
Language:English
Subjects:
Chemical compounds
Cytotoxicity
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Summary:Two new lathyrane diterpenoids, euphofischers A and B (1 and 2), along with three known analogues (3-5), were isolated from the roots of Euphorbia fischeriana. Their structures were elucidated by spectroscopic analysis. Euphofischer A (1) represents rare example of a lathyrane diterpenoid featuring a 15-p-coumaroyl moiety. All compounds were screened for their cytotoxicity against three cancer cell lines (C4-2B, C42B/ENZR, and MDA-MB-231), and compound 1 exhibited significant cytotoxicity against C4-2B cell line, with an IC50 value of 11.3 mM.
ISSN:1307-6167
1307-6167
DOI:10.25135/rnp.167.19.12.1496