Controlled Synthesis of Ag2Te@Ag2S Core–Shell Quantum Dots with Enhanced and Tunable Fluorescence in the Second Near‐Infrared Window

• Published in: Small (Weinheim an der Bergstrasse, Germany) Germany), 2020-04, Vol.16 (14), p.n/a
• Main Authors: Zhang, Yejun, Yang, Hongchao, An, Xinyi, Wang, Zan, Yang, Xiaohu, Yu, Mengxuan, Zhang, Rong, Sun, Ziqiang, Wang, Qiangbin
• Format: Article
• Language: English
• Subjects: Ag 2Te@Ag 2S; Biocompatibility; bioimaging; Biomedical materials; Chemical compounds; core–shell quantum dots; Fluorescence; Infrared windows; Medical imaging; Nanotechnology; NIR‐II nanoprobes; Organs; Penetration depth; Photoluminescence; Quantum dots; Silver compounds; Spatial resolution; Stability; Tellurides
• ISSN: 1613-6810; 1613-6829
• DOI: 10.1002/smll.202001003

Fluorescence in the second near‐infrared window (NIR‐II, 900–1700 nm) has drawn great interest for bioimaging, owing to its high tissue penetration depth and high spatiotemporal resolution. NIR‐II fluorophores with high photoluminescence quantum yield (PLQY) and stability along with high biocompatibility are urgently pursued. In this work, a Ag‐rich Ag2Te quantum dots (QDs) surface with sulfur source is successfully engineered to prepare a larger bandgap of Ag2S shell to passivate the Ag2Te core via a facile colloidal route, which greatly enhances the PLQY of Ag2Te QDs and significantly improves the stability of Ag2Te QDs. This strategy works well with different sized core Ag2Te QDs so that the NIR‐II PL can be tuned in a wide range. In vivo imaging using the as‐prepared Ag2Te@Ag2S QDs presents much higher spatial resolution images of organs and vascular structures as compared with the same dose of Ag2Te nanoprobes administrated, suggesting the success of the core–shell synthetic strategy and the potential biomedical applications of core–shell NIR‐II nanoprobes. Ag2Te@Ag2S core–shell quantum dots (QDs) with tunable emission are successfully prepared from the NIR‐IIa to NIR‐IIb window via a facile colloidal route, which greatly enhances the quantum yield of Ag2Te QDs and significantly improves the stability of Ag2Te QDs. In vivo imaging results suggest the advantages and potential biomedical applications of the new NIR‐II nanoprobes.