Synthesis of novel bis‐ and poly(benzimidazoles) as well as bis‐ and poly(benzothiazoles) as anticancer agents

A synthesis of bis‐ and poly(benzimidazoles) as well as bis‐ and poly(benzothiazoles) was attempted using different protocols. The best results were obtained by employing the reaction of the appropriate bis‐ or poly(aldehydes) with o‐phenylenediamine or 2‐aminothiophenol, respectively, in ethanol at...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2020-05, Vol.57 (5), p.2256-2270
Main Authors: Hebishy, Ali M. S., Abdelfattah, Mohamed S., Elmorsy, Abdullah, Elwahy, Ahmed H. M.
Format: Article
Language:English
Subjects:
Aldehydes
Anticancer properties
Biotechnology
Cancer
Ethanol
Phenylenediamine
Synthesis
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Summary:A synthesis of bis‐ and poly(benzimidazoles) as well as bis‐ and poly(benzothiazoles) was attempted using different protocols. The best results were obtained by employing the reaction of the appropriate bis‐ or poly(aldehydes) with o‐phenylenediamine or 2‐aminothiophenol, respectively, in ethanol at reflux in the presence of NaHSO3. The anticancer activities of the synthesized compounds were evaluated against human breast adenocarcinoma cell line (MCF‐7), liver cancer cell line (HepG‐2), and epithelial colorectal adenocarcinoma cells (CaCO‐2). Hexakis(benzothiazole) was found to exhibit the highest activity against HepG‐2 and MCF‐7 cell lines with IC50 values of 21.16 and 13.25 μM, respectively.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.3947