Design, synthesis of tri‐substituted pyrazole derivatives as promising antimicrobial agents and investigation of structure activity relationships

The major diseases spread in the environment only because of microbes. Even, intensive care units in the hospitals are polluted by microorganisms, particularly, Gram‐positive bacteria. Although many antibiotics are existed, there is a need to develop up to date microbial‐resistant agents. Hence, the...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2020-05, Vol.57 (5), p.2288-2296
Main Authors: Reddy, Guda Mallikarjuna, Garcia, Jarem Raul, Yuvaraja, Gutha, Venkata Subbaiah, Munagapati, Wen, Jet‐Chau
Format: Article
Language:English
Subjects:
Amalgams
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
Microorganisms
Pyrazole
Substitutes
Viability
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Summary:The major diseases spread in the environment only because of microbes. Even, intensive care units in the hospitals are polluted by microorganisms, particularly, Gram‐positive bacteria. Although many antibiotics are existed, there is a need to develop up to date microbial‐resistant agents. Hence, the current study aimed to develop prominent antimicrobial drug‐related compounds. Thus, a novel series of tri‐substituted analogs and their intermediates were synthesized. In addition, total new compounds were screened for their antimicrobial assay and identified as the most efficient biologically active compounds. Moreover, minimal inhibitory antimicrobial activity and appropriate structure activity relationships were investigated. From the results it was observed that, viability of Gram‐positive bacteria was most powerfully affected by all active compounds. Finally, this research demonstrated that, these biologically energetic amalgams can be utilized for further preclinical studies with the ambition of standing unique inventive drugs.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.3952