Continuing treatment of panic disorder after acute response: randomised, placebo-controlled trial with fluoxetine

BackgroundData concerning appropriate treatment in panic disorder following an initial response to acute therapy are limited.AimsTo assess the safety and efficacy of continued fluoxetine treatment following successful acute therapy of panic disorder.MethodPatients who responded to acute fluoxetine t...

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Bibliographic Details
Published in:British journal of psychiatry 1999-03, Vol.174 (3), p.213-218
Main Authors: Michelson, David, Pollack, Mark, Lydiard, R. Bruce, Tamura, Roy, Tepner, Rosalinda, Tollefson, Gary
Format: Article
Language:English
Subjects:
Antidepressants
Anxiety
Clinical outcomes
Efficacy
Fluoxetine
Mental depression
Panic attacks
Panic disorders
Statistical analysis
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Summary:BackgroundData concerning appropriate treatment in panic disorder following an initial response to acute therapy are limited.AimsTo assess the safety and efficacy of continued fluoxetine treatment following successful acute therapy of panic disorder.MethodPatients who responded to acute fluoxetine treatment were randomised to 24 weeks of continued fluoxetine or placebo.ResultsFluoxetine responders randomised to continue on their acute-phase fluoxetine dose experienced statistically significant improvement in panic attack frequency and phobia rating scale score over 24 weeks of therapy, while those switched to placebo experienced statistically significant worsening in Hamilton Anxiety (HAM–A), Hamilton Depression (HAM–D) and SCL–90–R rating scores.ConclusionsFluoxetine was associated with improved clinical outcomes compared with placebo during continuation therapy.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.174.3.213