MicroRNA‑431 inhibits the expression of surfactant proteins through the BMP4/activin/TGF‑β signaling pathway by targeting SMAD4

The synthesis and secretion of surfactant proteins (SPs) is an important sign of lung maturation. Furthermore, the morbidity of lung developmental diseases, including respiratory distress syndrome and bronchopulmonary dysplasia which are mainly caused by immature lung development and lack of SPs, is...

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Bibliographic Details
Published in:International journal of molecular medicine 2020-05, Vol.45 (5), p.1571-1582
Main Authors: Shen, Yan‑Qing, Bao, Zhi‑Dan, Pan, Jing‑Jing, Mao, Xiao‑Nan, Cheng, Rui, Zhou, Xiao‑Guang, Zhou, Xiao‑Yu, Yang, Yang
Format: Article
Language:English
Subjects:
Adenoviruses
Cloning
Genes
MicroRNAs
Newborn babies
Premature birth
Proteins
Respiratory diseases
Respiratory distress syndrome
Surfactants
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Summary:The synthesis and secretion of surfactant proteins (SPs) is an important sign of lung maturation. Furthermore, the morbidity of lung developmental diseases, including respiratory distress syndrome and bronchopulmonary dysplasia which are mainly caused by immature lung development and lack of SPs, is increasing. As is well known, multiple microRNAs (miRs/miRNAs) are able to influence lung development via numerous different signaling pathways. However, few studies examine the association between the miRNAs and lung developmental diseases. A previous study has demonstrated that miR-431 was significantly (F=33.49; P
ISSN:1107-3756
1791-244X
DOI:10.3892/ijmm.2020.4511