Five new flavonoid glycosides from Nervilia fordii

Five new flavonoid glycosides, namely nervilifordins F–J (1–5), were isolated from the 60% EtOH extract of the aerial parts of Nervilia fordii, along with three first isolated flavonoids (7, 8, and 13) and five known flavonoids (6, 9–12). The structures of new compounds were elucidated on the basis...

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Bibliographic Details
Published in:Journal of Asian Natural Products Research 2013, Vol.15 (6), p.589
Main Authors: Qiu, Li, Jiao, Yang, Ji-Zhao, Xie, Gui-Kun Huang, Shao-Ling, Qiu, Jian-Hua Miao, Xin-Sheng, Yao
Format: Web Resource
Language:English
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Summary:Five new flavonoid glycosides, namely nervilifordins F–J (1–5), were isolated from the 60% EtOH extract of the aerial parts of Nervilia fordii, along with three first isolated flavonoids (7, 8, and 13) and five known flavonoids (6, 9–12). The structures of new compounds were elucidated on the basis of 1D and 2D NMR and MS studies. Their anti-inflammatory activities were tested by measuring their inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages. Compounds 2 and 5 showed interesting inhibition effects with their EC50 values of 15.15 μM and 14.80 μM, respectively.