PEGylated hollow pH‐responsive polymeric nanocapsules for controlled drug delivery

Novel pH‐responsive PEGylated hollow nanocapsules (HNCaps) were fabricated through a combination of distillation–precipitation copolymerization and surface thiol–ene ‘click’ grafting reaction. For this purpose, SiO2 nanoparticles were synthesized using the Stöber approach, and then modified using 3‐...

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Bibliographic Details
Published in:Polymer international 2020-05, Vol.69 (5), p.519-527
Main Authors: Massoumi, Bakhshali, Abbasian, Mojtaba, Jahanban‐Esfahlan, Rana, Motamedi, Sanaz, Samadian, Hadi, Rezaei, Aram, Derakhshankhah, Hossein, Farnudiyan‐Habibi, Amir, Jaymand, Mehdi
Format: Article
Language:English
Subjects:
Acrylic acid
Anticancer properties
Antitumor activity
Breast cancer
Cancer
cancer chemotherapy
Chemical precipitation
Chemotherapy
Copolymerization
Crosslinking
Cytotoxicity
Distillation
Doxorubicin
Drug delivery
Drug delivery systems
Graft copolymers
hollow nanocapsules
nanomedicine
Nanoparticles
PEGylation
pH effects
pH‐responsive
Polyethylene glycol
Silicon dioxide
Toxicity
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Summary:Novel pH‐responsive PEGylated hollow nanocapsules (HNCaps) were fabricated through a combination of distillation–precipitation copolymerization and surface thiol–ene ‘click’ grafting reaction. For this purpose, SiO2 nanoparticles were synthesized using the Stöber approach, and then modified using 3‐(trimethoxysilyl)propyl methacrylate (MPS). Afterward, a mixture of triethyleneglycol dimethacrylate (as crosslinker), acrylic acid (AA; as pH‐responsive monomer) and MPS‐modified SiO2 nanoparticles (as sacrificial template) was copolymerized using the distillation–precipitation approach to afford SiO2@PAA core–shell nanoparticles. The SiO2 core was etched from SiO2@PAA using HF solution, and the obtained PAA HNCaps were grafted with a thiol‐end‐capped poly(ethylene glycol) (PEG) through a thiol–ene ‘click’ reaction to produce PAA‐g‐PEG HNCaps. The fabricated HNCaps were loaded with doxorubicin hydrochloride (DOX) as a model anticancer drug, and their drug loading and encapsulation efficiencies as well as pH‐dependent drug release behavior were investigated. The anticancer activity of the drug‐loaded HNCaps was extensively evaluated using MTT assay against human breast cancer cells (MCF7). The cytotoxicity assay results as well as superior physicochemical and biological features of the fabricated HNCaps mean that the developed DOX‐loaded HNCaps have excellent potential for cancer chemotherapy. © 2020 Society of Chemical Industry Novel PEGylated hollow pH‐responsive PAA‐based polymeric nanocapsules were fabricated through a combination of distillation–precipitation copolymerization and surface thiol‐ene “click” grafting reaction, and their performance as “smart” anti‐cancer carriers was investigated preliminary.
ISSN:0959-8103
1097-0126
DOI:10.1002/pi.5987