Effect of Gd and Dy Concentrations in Layered Double Hydroxides on Contrast in Magnetic Resonance Imaging

In this work, we explore the synthesis of layered double hydroxide (LDH) particles containing different molar ratios of Gd3+ and Dy3+ cations. A single crystalline phase was obtained for Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH, and their efficiency as contrast agents was evaluat...

Full description

Saved in:
Bibliographic Details
Published in:Processes 2020-04, Vol.8 (4), p.462
Main Authors: Nava Andrade, Karina, Carbajal Arízaga, Gregorio Guadalupe, Rivera Mayorga, José Antonio
Format: Article
Language:English
Subjects:
Anions
Cations
Contrast agents
Dysprosium
Gadolinium
Health care
Hydroxides
Lanthanides
Magnetic fields
Magnetic resonance imaging
Nitrates
Spectrum analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c292t-dcefd0b71719e09c131f7a449bec4ff0d5abed67d0927e305f89740f65f721683
cites cdi_FETCH-LOGICAL-c292t-dcefd0b71719e09c131f7a449bec4ff0d5abed67d0927e305f89740f65f721683
container_end_page
container_issue 4
container_start_page 462
container_title Processes
container_volume 8
creator Nava Andrade, Karina
Carbajal Arízaga, Gregorio Guadalupe
Rivera Mayorga, José Antonio
description In this work, we explore the synthesis of layered double hydroxide (LDH) particles containing different molar ratios of Gd3+ and Dy3+ cations. A single crystalline phase was obtained for Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH, and their efficiency as contrast agents was evaluated by T1- and T2-weighted magnetic resonance imaging (MRI). Both GdDy-LDHs exhibited longitudinal relaxivity (r1) higher than a commercial reference. The highest contrast in the T1 mode was achieved with the Zn2.0Al0.75Gd0.125Dy0.125-LDH, which contained the lowest concentration of lanthanides; this efficiency is related to the lowest amount of carbonate anions complexing the lanthanide sites. On the contrary, the best contrast in the T2 mode was achieved with Zn2.0Al0.5Gd0.25Dy0.25-LDH. Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH presented r2/r1 ratios of 7.9 and 22.5, respectively, indicating that the inclusion of gadolinium and dysprosium into layered structures is a promising approach to the development of efficient bimodal (T1/T2) MRI contrast agents.
doi_str_mv 10.3390/pr8040462
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2391253051</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2391253051</sourcerecordid><originalsourceid>FETCH-LOGICAL-c292t-dcefd0b71719e09c131f7a449bec4ff0d5abed67d0927e305f89740f65f721683</originalsourceid><addsrcrecordid>eNpNkE9LAzEQxYMoWGoPfoOAJw-r-bO72Ryl1rZQEUTPSzaZlC1tUpMsuN_elIo4lxmY37w3PIRuKXngXJLHY2hIScqaXaAJY0wUUlBx-W--RrMYdySXpLyp6gnqF9aCTthbvDRYOYOfRzz3ToNLQaXeu4h7hzdqhAB56YduD3g1muC_ewMRe3fCMxvTCXxVWwep1_gdoncq6-D1QW17t71BV1btI8x--xR9viw-5qti87Zcz582hWaSpcJosIZ0-VkqgUhNObVClaXsQJfWElOpDkwtDJFMACeVbaQoia0rKxitGz5Fd2fdY_BfA8TU7vwQXLZsGZeUVfmGZur-TOngYwxg22PoDyqMLSXtKcz2L0z-A5PkZnk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2391253051</pqid></control><display><type>article</type><title>Effect of Gd and Dy Concentrations in Layered Double Hydroxides on Contrast in Magnetic Resonance Imaging</title><source>Publicly Available Content Database</source><creator>Nava Andrade, Karina ; Carbajal Arízaga, Gregorio Guadalupe ; Rivera Mayorga, José Antonio</creator><creatorcontrib>Nava Andrade, Karina ; Carbajal Arízaga, Gregorio Guadalupe ; Rivera Mayorga, José Antonio</creatorcontrib><description>In this work, we explore the synthesis of layered double hydroxide (LDH) particles containing different molar ratios of Gd3+ and Dy3+ cations. A single crystalline phase was obtained for Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH, and their efficiency as contrast agents was evaluated by T1- and T2-weighted magnetic resonance imaging (MRI). Both GdDy-LDHs exhibited longitudinal relaxivity (r1) higher than a commercial reference. The highest contrast in the T1 mode was achieved with the Zn2.0Al0.75Gd0.125Dy0.125-LDH, which contained the lowest concentration of lanthanides; this efficiency is related to the lowest amount of carbonate anions complexing the lanthanide sites. On the contrary, the best contrast in the T2 mode was achieved with Zn2.0Al0.5Gd0.25Dy0.25-LDH. Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH presented r2/r1 ratios of 7.9 and 22.5, respectively, indicating that the inclusion of gadolinium and dysprosium into layered structures is a promising approach to the development of efficient bimodal (T1/T2) MRI contrast agents.</description><identifier>ISSN: 2227-9717</identifier><identifier>EISSN: 2227-9717</identifier><identifier>DOI: 10.3390/pr8040462</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Anions ; Cations ; Contrast agents ; Dysprosium ; Gadolinium ; Health care ; Hydroxides ; Lanthanides ; Magnetic fields ; Magnetic resonance imaging ; Nitrates ; Spectrum analysis</subject><ispartof>Processes, 2020-04, Vol.8 (4), p.462</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c292t-dcefd0b71719e09c131f7a449bec4ff0d5abed67d0927e305f89740f65f721683</citedby><cites>FETCH-LOGICAL-c292t-dcefd0b71719e09c131f7a449bec4ff0d5abed67d0927e305f89740f65f721683</cites><orcidid>0000-0003-3120-0243 ; 0000-0002-0426-229X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2391253051/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2391253051?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25752,27923,27924,37011,44589,74897</link.rule.ids></links><search><creatorcontrib>Nava Andrade, Karina</creatorcontrib><creatorcontrib>Carbajal Arízaga, Gregorio Guadalupe</creatorcontrib><creatorcontrib>Rivera Mayorga, José Antonio</creatorcontrib><title>Effect of Gd and Dy Concentrations in Layered Double Hydroxides on Contrast in Magnetic Resonance Imaging</title><title>Processes</title><description>In this work, we explore the synthesis of layered double hydroxide (LDH) particles containing different molar ratios of Gd3+ and Dy3+ cations. A single crystalline phase was obtained for Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH, and their efficiency as contrast agents was evaluated by T1- and T2-weighted magnetic resonance imaging (MRI). Both GdDy-LDHs exhibited longitudinal relaxivity (r1) higher than a commercial reference. The highest contrast in the T1 mode was achieved with the Zn2.0Al0.75Gd0.125Dy0.125-LDH, which contained the lowest concentration of lanthanides; this efficiency is related to the lowest amount of carbonate anions complexing the lanthanide sites. On the contrary, the best contrast in the T2 mode was achieved with Zn2.0Al0.5Gd0.25Dy0.25-LDH. Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH presented r2/r1 ratios of 7.9 and 22.5, respectively, indicating that the inclusion of gadolinium and dysprosium into layered structures is a promising approach to the development of efficient bimodal (T1/T2) MRI contrast agents.</description><subject>Anions</subject><subject>Cations</subject><subject>Contrast agents</subject><subject>Dysprosium</subject><subject>Gadolinium</subject><subject>Health care</subject><subject>Hydroxides</subject><subject>Lanthanides</subject><subject>Magnetic fields</subject><subject>Magnetic resonance imaging</subject><subject>Nitrates</subject><subject>Spectrum analysis</subject><issn>2227-9717</issn><issn>2227-9717</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpNkE9LAzEQxYMoWGoPfoOAJw-r-bO72Ryl1rZQEUTPSzaZlC1tUpMsuN_elIo4lxmY37w3PIRuKXngXJLHY2hIScqaXaAJY0wUUlBx-W--RrMYdySXpLyp6gnqF9aCTthbvDRYOYOfRzz3ToNLQaXeu4h7hzdqhAB56YduD3g1muC_ewMRe3fCMxvTCXxVWwep1_gdoncq6-D1QW17t71BV1btI8x--xR9viw-5qti87Zcz582hWaSpcJosIZ0-VkqgUhNObVClaXsQJfWElOpDkwtDJFMACeVbaQoia0rKxitGz5Fd2fdY_BfA8TU7vwQXLZsGZeUVfmGZur-TOngYwxg22PoDyqMLSXtKcz2L0z-A5PkZnk</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Nava Andrade, Karina</creator><creator>Carbajal Arízaga, Gregorio Guadalupe</creator><creator>Rivera Mayorga, José Antonio</creator><general>MDPI AG</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>LK8</scope><scope>M7P</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0003-3120-0243</orcidid><orcidid>https://orcid.org/0000-0002-0426-229X</orcidid></search><sort><creationdate>20200401</creationdate><title>Effect of Gd and Dy Concentrations in Layered Double Hydroxides on Contrast in Magnetic Resonance Imaging</title><author>Nava Andrade, Karina ; Carbajal Arízaga, Gregorio Guadalupe ; Rivera Mayorga, José Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c292t-dcefd0b71719e09c131f7a449bec4ff0d5abed67d0927e305f89740f65f721683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anions</topic><topic>Cations</topic><topic>Contrast agents</topic><topic>Dysprosium</topic><topic>Gadolinium</topic><topic>Health care</topic><topic>Hydroxides</topic><topic>Lanthanides</topic><topic>Magnetic fields</topic><topic>Magnetic resonance imaging</topic><topic>Nitrates</topic><topic>Spectrum analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nava Andrade, Karina</creatorcontrib><creatorcontrib>Carbajal Arízaga, Gregorio Guadalupe</creatorcontrib><creatorcontrib>Rivera Mayorga, José Antonio</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Processes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nava Andrade, Karina</au><au>Carbajal Arízaga, Gregorio Guadalupe</au><au>Rivera Mayorga, José Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Gd and Dy Concentrations in Layered Double Hydroxides on Contrast in Magnetic Resonance Imaging</atitle><jtitle>Processes</jtitle><date>2020-04-01</date><risdate>2020</risdate><volume>8</volume><issue>4</issue><spage>462</spage><pages>462-</pages><issn>2227-9717</issn><eissn>2227-9717</eissn><abstract>In this work, we explore the synthesis of layered double hydroxide (LDH) particles containing different molar ratios of Gd3+ and Dy3+ cations. A single crystalline phase was obtained for Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH, and their efficiency as contrast agents was evaluated by T1- and T2-weighted magnetic resonance imaging (MRI). Both GdDy-LDHs exhibited longitudinal relaxivity (r1) higher than a commercial reference. The highest contrast in the T1 mode was achieved with the Zn2.0Al0.75Gd0.125Dy0.125-LDH, which contained the lowest concentration of lanthanides; this efficiency is related to the lowest amount of carbonate anions complexing the lanthanide sites. On the contrary, the best contrast in the T2 mode was achieved with Zn2.0Al0.5Gd0.25Dy0.25-LDH. Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH presented r2/r1 ratios of 7.9 and 22.5, respectively, indicating that the inclusion of gadolinium and dysprosium into layered structures is a promising approach to the development of efficient bimodal (T1/T2) MRI contrast agents.</abstract><cop>Basel</cop><pub>MDPI AG</pub><doi>10.3390/pr8040462</doi><orcidid>https://orcid.org/0000-0003-3120-0243</orcidid><orcidid>https://orcid.org/0000-0002-0426-229X</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2227-9717
ispartof Processes, 2020-04, Vol.8 (4), p.462
issn 2227-9717
2227-9717
language eng
recordid cdi_proquest_journals_2391253051
source Publicly Available Content Database
subjects Anions
Cations
Contrast agents
Dysprosium
Gadolinium
Health care
Hydroxides
Lanthanides
Magnetic fields
Magnetic resonance imaging
Nitrates
Spectrum analysis
title Effect of Gd and Dy Concentrations in Layered Double Hydroxides on Contrast in Magnetic Resonance Imaging
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T04%3A12%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Gd%20and%20Dy%20Concentrations%20in%20Layered%20Double%20Hydroxides%20on%20Contrast%20in%20Magnetic%20Resonance%20Imaging&rft.jtitle=Processes&rft.au=Nava%20Andrade,%20Karina&rft.date=2020-04-01&rft.volume=8&rft.issue=4&rft.spage=462&rft.pages=462-&rft.issn=2227-9717&rft.eissn=2227-9717&rft_id=info:doi/10.3390/pr8040462&rft_dat=%3Cproquest_cross%3E2391253051%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c292t-dcefd0b71719e09c131f7a449bec4ff0d5abed67d0927e305f89740f65f721683%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2391253051&rft_id=info:pmid/&rfr_iscdi=true