Correction of Lipid Metabolism Disorders in Diabetes Mellitus with Peptide Drugs

We studied the effect of peptide drugs deltalicin and Semax on lipid metabolism disturbances in diabetes mellitus. Diabetes mellitus was modeled by single injection of streptozotocin (45 mg/kg) and rats with blood glucose ≥12 mmol/liter were selected for the further experiments. Deltalicin in a dose...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2020-03, Vol.168 (5), p.618-620
Main Authors: Elagina, A. A., Lyashev, Yu. D., Lyashev, A. Yu, Pronyaeva, T. V., Chahine, A. R.
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - analogs & derivatives
Adrenocorticotropic Hormone - therapeutic use
Animals
Biomedical and Life Sciences
Biomedicine
Blood sugar
Cell Biology
Cholesterol
Diabetes
Diabetes mellitus
Diabetes Mellitus, Experimental - chemically induced
Diabetes Mellitus, Experimental - complications
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
Diabetes therapy
Drug dosages
Drug therapy
Drugs
Glucose
Glycosaminoglycans - pharmacology
Glycosaminoglycans - therapeutic use
High density lipoprotein
Hypolipidemic Agents - therapeutic use
Internal Medicine
Laboratory Medicine
Lipid metabolism
Lipid Metabolism - drug effects
Lipid Metabolism Disorders - complications
Lipid Metabolism Disorders - drug therapy
Lipids
Low density lipoprotein
Low density lipoproteins
Male
Metabolic disorders
Pathology
Peptide Fragments - therapeutic use
Peptides
Peptides - therapeutic use
Physiological aspects
Rats
Rats, Wistar
Streptozocin
Triglycerides
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Summary:We studied the effect of peptide drugs deltalicin and Semax on lipid metabolism disturbances in diabetes mellitus. Diabetes mellitus was modeled by single injection of streptozotocin (45 mg/kg) and rats with blood glucose ≥12 mmol/liter were selected for the further experiments. Deltalicin in a dose 100 μg/kg and Semax in a dose 200 μg/kg as well as sulodexide corrected lipid metabolism disorders: the content of total cholesterol, triglycerides, LDL, index of atherogenicity decreased and HDL concentration increased. Deltalicin produced more potent effect on lipid metabolism in rats with diabetes mellitus than sulodexide and Semax, which manifested in a significant decrease in total cholesterol and LDL concentration and index of atherogenicity.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-04764-2