Evaluation of Applicability of Aminodiphosphonic Acids for the Development of Bone-Seeking 68Ga-Radiopharmaceuticals

The binding of 68 Ga to two organic ligands containing aminodiphosphonic groups (1,7-diamino-4-oxaheptane-1,1,7,7-tetraphosphonic and 1,7-diamino-4-hydroxycarbonylheptane-1,1,7,7-tetraphosphonic acids) has been examined. The stability and osteotropic potential of the labeled compounds have been eval...

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Bibliographic Details
Published in:Russian journal of general chemistry 2020, Vol.90 (3), p.390-397
Main Authors: Mitrofanov, Iu. A., Maruk, A. Ya, Larenkov, A. A., Kodina, G. E., Lunev, A. S., Luneva, K. A., Klementyeva, O. E., Tsebrikova, G. S., Baulin, V. E., Ragulin, V. V., Tsivadze, A. Yu
Format: Article
Language:English
Subjects:
Biomedical materials
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Evaluation
Stability analysis
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Summary:The binding of 68 Ga to two organic ligands containing aminodiphosphonic groups (1,7-diamino-4-oxaheptane-1,1,7,7-tetraphosphonic and 1,7-diamino-4-hydroxycarbonylheptane-1,1,7,7-tetraphosphonic acids) has been examined. The stability and osteotropic potential of the labeled compounds have been evaluated.
ISSN:1070-3632
1608-3350
DOI:10.1134/S107036322003010X